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Publisher DOI: 10.3390/polym12020273
Title: Jet cutting technique for the production of chitosan aerogel microparticles loaded with vancomycin
Language: English
Authors: López-Iglesias, Clara 
Barros, Joana 
Ardao, Inés 
Gurikov, Pavel 
Monteiro, Fernando 
Smirnova, Irina 
Alvarez-Lorenzo, Carmen 
García-González, Carlos A. 
Keywords: biopolymers;polymer processing;biomedical applications;wound treatment;chitosan;aerogels
Issue Date: 29-Jan-2020
Publisher: Multidisciplinary Digital Publishing Institute
Source: Polymers 12 (2): 273 (2020)
Journal or Series Name: Polymers 
Abstract (english): Biopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.
DOI: 10.15480/882.2693
ISSN: 2073-4360
Institute: Entwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2 
Thermische Verfahrenstechnik V-8 
Type: (wissenschaftlicher) Artikel
Funded by: Xunta de Galicia
Agrupación Estratégica de Materiales
Agencia Estatal de Investigación
FEDER funds
European Commission
Project: COST Action CA18125 “Advanced Engineering and Research of aeroGels for Environment and Life Sciences” (AERoGELS) 
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