Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.2693
DC FieldValueLanguage
dc.contributor.authorLópez-Iglesias, Clara-
dc.contributor.authorBarros, Joana-
dc.contributor.authorArdao, Inés-
dc.contributor.authorGurikov, Pavel-
dc.contributor.authorMonteiro, Fernando-
dc.contributor.authorSmirnova, Irina-
dc.contributor.authorAlvarez-Lorenzo, Carmen-
dc.contributor.authorGarcía-González, Carlos A.-
dc.date.accessioned2020-03-04T12:10:05Z-
dc.date.available2020-03-04T12:10:05Z-
dc.date.issued2020-01-29-
dc.identifier.citationPolymers 12 (2): 273 (2020)de_DE
dc.identifier.issn2073-4360de_DE
dc.identifier.urihttp://hdl.handle.net/11420/5158-
dc.description.abstractBiopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.en
dc.description.sponsorshipXunta de Galiciade_DE
dc.description.sponsorshipAgrupación Estratégica de Materialesde_DE
dc.description.sponsorshipAgencia Estatal de Investigaciónde_DE
dc.description.sponsorshipFEDER fundsde_DE
dc.description.sponsorshipMINECOde_DE
dc.description.sponsorshipEuropean Commissionde_DE
dc.language.isoende_DE
dc.publisherMultidisciplinary Digital Publishing Institutede_DE
dc.relation.ispartofPolymersde_DE
dc.rightsCC BY 4.0de_DE
dc.subjectbiopolymersde_DE
dc.subjectpolymer processingde_DE
dc.subjectbiomedical applicationsde_DE
dc.subjectwound treatmentde_DE
dc.subjectchitosande_DE
dc.subjectaerogelsde_DE
dc.subject.ddc540: Chemiede_DE
dc.subject.ddc570: Biowissenschaften, Biologiede_DE
dc.subject.ddc610: Medizinde_DE
dc.titleJet cutting technique for the production of chitosan aerogel microparticles loaded with vancomycinde_DE
dc.typeArticlede_DE
dc.date.updated2020-03-02T12:39:13Z-
dc.identifier.doi10.15480/882.2693-
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-882.075982-
tuhh.oai.showtruede_DE
tuhh.abstract.englishBiopolymer-based aerogels can be obtained by supercritical drying of wet gels and endowed with outstanding properties for biomedical applications. Namely, polysaccharide-based aerogels in the form of microparticles are of special interest for wound treatment and can also be loaded with bioactive agents to improve the healing process. However, the production of the precursor gel may be limited by the viscosity of the polysaccharide initial solution. The jet cutting technique is regarded as a suitable processing technique to overcome this problem. In this work, the technological combination of jet cutting and supercritical drying of gels was assessed to produce chitosan aerogel microparticles loaded with vancomycin HCl (antimicrobial agent) for wound healing purposes. The resulting aerogel formulation was evaluated in terms of morphology, textural properties, drug loading, and release profile. Aerogels were also tested for wound application in terms of exudate sorption capacity, antimicrobial activity, hemocompatibility, and cytocompatibility. Overall, the microparticles had excellent textural properties, absorbed high amounts of exudate, and controlled the release of vancomycin HCl, providing sustained antimicrobial activity.de_DE
tuhh.publisher.doi10.3390/polym12020273-
tuhh.publication.instituteEntwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2de_DE
tuhh.publication.instituteThermische Verfahrenstechnik V-8de_DE
tuhh.identifier.doi10.15480/882.2693-
tuhh.type.opus(wissenschaftlicher) Artikel-
openaire.funder.projectidCA18125de_DE
dc.type.driverarticle-
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/de_DE
dc.type.casraiJournal Article-
tuhh.container.issue2de_DE
tuhh.container.volume12de_DE
dc.relation.projectCOST Action CA18125 “Advanced Engineering and Research of aeroGels for Environment and Life Sciences” (AERoGELS)de_DE
dc.rights.nationallicensefalsede_DE
tuhh.container.articlenumber273de_DE
local.status.inpressfalsede_DE
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextWith Fulltext-
item.creatorOrcidLópez-Iglesias, Clara-
item.creatorOrcidBarros, Joana-
item.creatorOrcidArdao, Inés-
item.creatorOrcidGurikov, Pavel-
item.creatorOrcidMonteiro, Fernando-
item.creatorOrcidSmirnova, Irina-
item.creatorOrcidAlvarez-Lorenzo, Carmen-
item.creatorOrcidGarcía-González, Carlos A.-
item.openairetypeArticle-
item.languageiso639-1en-
item.creatorGNDLópez-Iglesias, Clara-
item.creatorGNDBarros, Joana-
item.creatorGNDArdao, Inés-
item.creatorGNDGurikov, Pavel-
item.creatorGNDMonteiro, Fernando-
item.creatorGNDSmirnova, Irina-
item.creatorGNDAlvarez-Lorenzo, Carmen-
item.creatorGNDGarcía-González, Carlos A.-
item.grantfulltextopen-
crisitem.author.deptEntwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.orcid0000-0002-5477-1762-
crisitem.author.orcid0000-0003-0598-243X-
crisitem.author.orcid0000-0002-1361-4605-
crisitem.author.orcid0000-0002-8546-7085-
crisitem.author.orcid0000-0001-9542-3679-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
Appears in Collections:Publications with fulltext
Files in This Item:
File Description SizeFormat
polymers-12-00273-v2.pdf1,83 MBAdobe PDFThumbnail
View/Open
Show simple item record

Google ScholarTM

Check

Note about this record

Export

This item is licensed under a Creative Commons License Creative Commons