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Publisher DOI: 10.1038/s41598-020-59573-4
Title: Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration
Language: English
Authors: Nebelung, Sven 
Dötsch, Lisa 
Shah, Dhaval 
Abrar, Daniel Benjamin 
Linka, Kevin 
Knobe, Matthias 
Sewerin, Philipp 
Thüring, Johannes 
Kuhl, Christiane 
Truhn, Daniel 
Issue Date: 12-Feb-2020
Publisher: Macmillan Publishers Limited
Source: Scientific Reports 1 (10): 2499 (2020)
Journal or Series Name: Scientific reports 
Abstract (english): Meniscus pathology may promote early osteoarthritis. This study assessed human meniscus functionality (i.e. its response to loading) ex vivo based on quantitative T1, T1ρ, and T2 mapping as a function of histological degeneration and loading. Forty-five meniscus samples of variable degeneration were harvested from the lateral meniscus body region of 45 patients during total knee arthroplasties. Samples underwent serial mapping on a 3.0-T MRI scanner (Achieva, Philips) using a force-controlled and torque-inducing compressive loading device. Samples were measured at three loading positions, i.e. unloaded, loaded to 2 bar (compression force 37 N) and 4 bar (69 N). Histology (Pauli classification) and biomechanics (Elastic Modulus) served as references. Based on histology, samples were trichotomized as grossly intact (n = 14), mildly degenerative (n = 16), and moderate-to-severely degenerative (n = 15) and analyzed using appropriate parametric and non-parametric tests. For T1, we found loading-induced decreases in all samples, irrespective of degeneration. For T1ρ, zonal increases in intact (apex) and decreases in degenerative samples (base) were found, while for T2, changes were ambiguous. In conclusion, force-controlled loading and serial MR imaging reveal response-to-loading patterns in meniscus. Zonal T1ρ response-to-loading patterns are most promising in differentiating degeneration, while T1 and T2 aren’t clearly related to degeneration.and may provide an imaging-based indication of functional tissue properties.
DOI: 10.15480/882.2698
ISSN: 2045-2322
Institute: Kontinuums- und Werkstoffmechanik M-15 
Type: (wissenschaftlicher) Artikel
Funded by: Deutsche Forschungsgemeinschaft (DFG) (NE3136/3-1) Grants (SN, 6917012; JT, 691905)
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