Publisher DOI: 10.2217/nnm-2019-0449
Title: Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes
Language: English
Authors: Antonelli, Antonella 
Szwargulski, Patryk 
Scarpa, Emanuele Salvatore 
Thieben, Florian  
Gruettner, Cordula 
Ambrosi, Gianluca 
Guidi, Loretta 
Ludewig, Peter 
Knopp, Tobias 
Magnani, Mauro 
Keywords: intravascular contrast agents;MPS/MPI;NMR;RBCs;SPIO-loaded RBCs;TEM
Issue Date: 1-Apr-2020
Source: Nanomedicine 8 (15): 739-753 (2020-04-01)
Journal: Nanomedicine 
Abstract (english): 
Aim: Magnetic particle imaging (MPI) is highly promising for biomedical applications, but optimal tracers for MPI, namely superparamagnetic iron oxide-based contrast agents, are still lacking. Materials & methods: The encapsulation of commercially available nanoparticles, specifically synomag®-D and perimag®, into human red blood cells (RBCs) was performed by a hypotonic dialysis and isotonic resealing procedure. The amounts of superparamagnetic iron oxide incorporated into RBCs were determined by Fe quantification using nuclear magnetic resonance and magnetic particle spectroscopy. Results: Perimag-COOH nanoparticles were identified as the best nanomaterial for encapsulation in RBCs. Perimag-COOH-loaded RBCs proved to be viable cells showing a good magnetic particle spectroscopy performance, while the magnetic signal of synomag-D-COOH-loaded RBCs dropped sharply. Conclusion: Perimag-COOH-loaded RBCs could be a potential tool for MPI diagnostic applications.
ISSN: 1748-6963
Institute: Biomedizinische Bildgebung E-5 
Document Type: Article
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