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Publisher DOI: 10.1002/ceat.201900517
Title: Contact behavior of microcrystalline cellulose pellets depending on their water content
Language: English
Authors: Grohn, Philipp 
Weis, Dominik 
Thommes, Markus 
Heinrich, Stefan 
Antonyuk, Sergiy 
Keywords: Compression test;Extrusion;Microcrystalline cellulose pellets;Spheronization;Water content
Issue Date: 12-Mar-2020
Publisher: Wiley-VCH Verl.-Ges.
Source: Chemical Engineering and Technology 5 (43): 887-895 (2020-05-01)
Journal or Series Name: Chemical engineering & technology 
Abstract (english): Microcrystalline cellulose pellets for oral drug delivery are often produced by a combined wet extrusion-spheronization process. During the entire process, the cylindrical as well as the spherical pellets are exposed to various stresses resulting in a change of their shape and size due to plastic deformation and breakage. In this work, the effect of moisture content of pellets on their mechanical behavior is studied. In static compression tests, the strong influence of water content on deformation behavior of pellets is confirmed. Moreover, impact tests are performed using a setup consisting of three high-speed cameras to record pellet-wall collisions. Material properties, such as stiffness, restitution coefficient, breakage force, and displacement, were analyzed depending on the water content.
DOI: 10.15480/882.2758
ISSN: 0930-7516
Institute: Feststoffverfahrenstechnik und Partikeltechnologie V-3 
Type: (wissenschaftlicher) Artikel
Funded by: This study was conducted within two research projects funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Project-ID AN 782/12-1 and AN 782/2-1.
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