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Publisher DOI: 10.1007/s00449-020-02300-0
Title: Co-cultures with integrated in situ product removal for lactate-based propionic acid production
Language: English
Authors: Selder, Ludwig 
Sabra, Wael 
Jürgensen, Nikolai 
Lakshmanan, Alagappan 
Zeng, An-Ping  
Keywords: Co-culture;Electrodialysis;In situ product removal;Propionic acid
Issue Date: 13-Feb-2020
Publisher: Springer
Source: Bioprocess and Biosystems Engineering 6 (43): 1027-1035 (2020-06-01)
Journal or Series Name: Bioprocess and biosystems engineering 
Abstract (english): Propionic acid (PA) is a valuable organic acid for the food and feed industry, but no bioproduction at industrial scale exists so far. As product inhibition is a major burden for bioprocesses producing organic acids, in situ product removal (ISPR) is desirable. Here, we demonstrate a new strategy to produce PA with a co-culture coupled with ISPR using electrodialysis. Specifically, Bacillus coagulans first produces lactic acid (LA) from sugar(s) and LA is converted to PA using Veillonella criceti. Applying ISPR to the mentioned co-culture, the specific PA yield was increased from 0.35 to 0.39 g g−1 compared to no ISPR usage. Furthermore, the productivity was increased from 0.63 to 0.7 g L−1 h−1 by applying ISPR. Additionally, it was shown that co-consumption of xylose and glucose led to a higher PA productivity of 0.73 g L−1 h−1, although PA yield was only increased slightly up to 0.36 g g−1.
DOI: 10.15480/882.2763
ISSN: 1615-7591
Institute: Bioprozess- und Biosystemtechnik V-1 
Type: (wissenschaftlicher) Artikel
Funded by: Support by ERA-IB-2 (7th call) project BIOCHEM (Novel BIOrefinery platform methodology for a driven production of CHEMicals from low-grade biomass, ERA-IB-16-052), funded by the German Ministry of Education and Research (031B0270) and the project ELBE-NH: Effektivitätssteigerung von Lignin Bioraffinerien durch ergänzende Nutzung von Hydrolysaten, funded by the German Ministry of Education and Research (031B0660E).
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