TUHH Open Research
Help
  • Log In
    New user? Click here to register.Have you forgotten your password?
  • English
  • Deutsch
  • Communities & Collections
  • Publications
  • Research Data
  • People
  • Institutions
  • Projects
  • Statistics
  1. Home
  2. TUHH
  3. Publication References
  4. A mechanical microconnector system for restoration of tissue continuity and long-term drug application into the injured spinal cord
 
Options

A mechanical microconnector system for restoration of tissue continuity and long-term drug application into the injured spinal cord

Publikationstyp
Journal Article
Date Issued
2013-10-03
Sprache
English
Author(s)
Brazda, Nicole  
Voss, Christian  
Estrada, Veronica  
Lodin, Homaira  
Weinrich, N.  
Seide, Klaus  
Müller, Jörg  
Müller, Hans Werner  
Institut
Mikrosystemtechnik E-7  
TORE-URI
http://hdl.handle.net/11420/6096
Journal
Biomaterials  
Volume
34
Issue
38
Start Page
10056
End Page
10064
Citation
Biomaterials 38 (34): 10056-10064 (2013)
Publisher DOI
10.1016/j.biomaterials.2013.09.057
Scopus ID
2-s2.0-84885385836
Publisher
Elsevier Science
Complete transection of the spinal cord leaves a gap of several mm which fills with fibrous scar tissue. Several approaches in rodent models have used tubes, foams, matrices or tissue implants to bridge this gap. Here, we describe a mechanical microconnector system (mMS) to re-adjust the retracted spinal cord stumps. The mMS is a multi-channel system of polymethylmethacrylate (PMMA), designed to fit into the spinal cord tissue gap after transection, with an outlet tubing system to apply negative pressure to the mMS thus sucking the spinal cord stumps into the honeycomb-structured holes. The stumps adhere to the microstructure of the mMS walls and remain in the mMS after removal of the vacuum. We show that the mMS preserves tissue integrity and allows axonal regrowth at 2, 5 and 19 weeks post lesion with no adverse tissue effects like in-bleeding or cyst formation. Preliminary assessment of locomotor function in the open field suggested beneficial effects of the mMS. Additional inner micro-channels enable local substance delivery into the lesion center via an attached osmotic minipump. We suggest that the mMS is a suitable device to adapt and stabilize the injured spinal cord after surgical resection of scar tissue (e.g., for chronic patients) or traumatic injuries with large tissue and bone damages.
Subjects
Neuronal regeneration
Polymethylmethacrylate
Soft tissue biomechanics
Spinal cord injury
Spinal surgery
DDC Class
610: Medizin
TUHH
Weiterführende Links
  • Contact
  • Send Feedback
  • Cookie settings
  • Privacy policy
  • Impress
DSpace Software

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science
Design by effective webwork GmbH

  • Deutsche NationalbibliothekDeutsche Nationalbibliothek
  • ORCiD Member OrganizationORCiD Member Organization
  • DataCiteDataCite
  • Re3DataRe3Data
  • OpenDOAROpenDOAR
  • OpenAireOpenAire
  • BASE Bielefeld Academic Search EngineBASE Bielefeld Academic Search Engine
Feedback