Publisher DOI: 10.1159/000505938
Title: Towards an Optical Biopsy during Visceral Surgical Interventions
Language: English
Authors: Ellebrecht, David Benjamin 
Latus, Sarah 
Schlaefer, Alexander 
Keck, Tobias 
Gessert, Nils Thorben 
Keywords: Confocal laser microscopy;Deep learning;Laparoscopy;Laparotomy;Optical coherence tomography;Surgery
Issue Date: 1-Apr-2020
Source: Visceral Medicine 2 (36): 70-79 (2020-04-01)
Journal or Series Name: Visceral medicine 
Abstract (english): Background: Cancer will replace cardiovascular diseases as the most frequent cause of death. Therefore, the goals of cancer treatment are prevention strategies and early detection by cancer screening and ideal stage therapy. From an oncological point of view, complete tumor resection is a significant prognostic factor. Optical coherence tomography (OCT) and confocal laser microscopy (CLM) are two techniques that have the potential to complement intraoperative frozen section analysis as in vivo and real-time optical biopsies. Summary: In this review we present both procedures and review the progress of evaluation for intraoperative application in visceral surgery. For visceral surgery, there are promising studies evaluating OCT and CLM; however, application during routine visceral surgical interventions is still lacking. Key Message: OCT and CLM are not competing but complementary approaches of tissue analysis to intraoperative frozen section analysis. Although intraoperative application of OCT and CLM is at an early stage, they are two promising techniques of intraoperative in vivo and real-time tissue examination. Additionally, deep learning strategies provide a significant supplement for automated tissue detection.
URI: http://hdl.handle.net/11420/6152
ISSN: 2297-475X
Institute: Medizintechnische Systeme E-1 
Type: Sonstiges
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