Microfluidic device for the continuous preparation of eukaryotic cells for metabolic analysis

Start Page
259
End Page
262
Article Number
6474227
Citation
IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013
Contribution to Conference
IEEE 26th International Conference on Micro Electro Mechanical Systems, MEMS 2013  
Publisher DOI
10.1109/MEMSYS.2013.6474227
Scopus ID
2-s2.0-84875438374
Publisher
IEEE
A novel lab-on-a-chip is presented for the high-throughput preparation of mammalian cell samples. The microfluidic chip consists of two temperature zones and five functional modules with a total number of four fluidic inlet and three outlet channels for sample collection. The key modules of the chip are a rapid split-and-recombine micromixer for biological system perturbation, a chaotic advection 'stirred' incubation channel for lowered residence time distribution, and a spiral channel for efficient particle separation and media exchange. The passive chip is suitable for dynamic pulse experiments for metabolic analyses in cell compartments.
DDC Class
570: Biowissenschaften, Biologie
600: Technik
620: Ingenieurwissenschaften
More Funding Information
Deutschland, Bundesministerium für Bildung und Forschung (BMBF)