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  4. Rückenmarkadaptation : bioresorbierbares Mikrosystem, Medikamentenapplikation, Stammzellen
 
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Rückenmarkadaptation : bioresorbierbares Mikrosystem, Medikamentenapplikation, Stammzellen

Other Titles
Spinal cord adaptation : bioresorbable microsystem, drug administration, stem cells
Publikationstyp
Journal Article
Date Issued
2013-09-05
Sprache
German
Author(s)
Seide, Klaus  
Voss, Christian  
Estrada, Veronica  
Brazda, Nicole  
Schira, Jessica  
Kehl, T.  
Antoni, V.  
Müller, Hans Werner  
Müller, Jörg  
Jürgens, Christian  
Faschingbauer, Maximilian  
Institut
Mikrosystemtechnik E-7  
TORE-URI
http://hdl.handle.net/11420/7059
Journal
Trauma und Berufskrankheit  
Volume
15
Issue
SUPPL. 2
Start Page
179
End Page
184
Citation
Trauma und Berufskrankheit SUPPL. 2 (15): 179-184 (2013)
Publisher DOI
10.1007/s10039-013-1950-9
Scopus ID
2-s2.0-84902543610
Publisher
Springer
Background. The idea behind the research project on neuroregeneration after spinal cord injury currently funded by the Deutsche Gesetzliche Unfallversicherung (DGUV) is to combine known drug and cell therapeutic approaches with a surgical procedure. Technique. Damaged spinal cord tissue is resected followed by a tension-free adaptation of the uninjured tissue. For this purpose, a connector element (mMS, mechanical micro-connector system) was developed based on microsystem technologies. The mMS additionally allows the administration of drugs via microchannels Animal trials. In a key experiment in rats, the fixation of the spinal cord tissue, regenerative axon growth through the mMS, and improvement of locomotor function was shown. Currently, further therapeutic combination strategies include the use of substances to reduce fibrotic scar formation, to digest proteoglycans that inhibit axonal growth, stem cells to stimulate axonal growth as well as the chemokine SDF1. Discussion. In order to enable a tension-free adaptation of healthy tissue, depending on the extent of the damage, a shortening of the corresponding spine segment may be necessary. This can be achieved by total vertebral resection. It is known from the literature that total removal of spine segments is technically possible. However, shortening the spine in the course of the treatment of spinal cord damage is new. By combining cellular pharmaceutical treatments with surgical mechanical procedures the neuroregenerative therapy of spinal cord injury seems possible. © 2013 Springer-Verlag Berlin Heidelberg.
Subjects
Mechanical connector element
Nerve regeneration
Spinal cord injuries
Spinal cord regeneration
Treatment approaches
DDC Class
610: Medizin
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