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Publisher DOI: 10.1016/j.supflu.2020.105012
Title: New insights in the morphological characterization and modelling of poly(ε-caprolactone) bone scaffolds obtained by supercritical CO₂ foaming
Language: English
Authors: Santos-Rosales, Víctor 
Gallo, Marta 
Jaeger, Philip 
Alvarez-Lorenzo, Carmen 
Gómez-Amoza, José Luis 
García-González, Carlos A. 
Keywords: 3D-biodegradable scaffolds; 3D-modelling; Bone regeneration; Pore interconnectivity; Supercritical foaming; X-ray microtomography
Issue Date: 7-Aug-2020
Publisher: Elsevier Science
Source: Journal of Supercritical Fluids (166): 105012 (2020-12-01)
Abstract (english): 
Hierarchically porous synthetic bone grafts (scaffolds) are gaining attention in the clinical arena. Scaffolds should combine morphological (macro- and microporosity, pore interconnectivity), mechanical and biological (biocompatibility, degradation rate) properties to fit this specific use. Supercritical (sc-) foaming is a versatile scaffold processing technology. However, the selection of the optimum operating conditions to obtain a defined scaffold structure is hampered by the lack of a single characterization technique able to fully elucidate the porous features of the resulting scaffolds. In this work, the effect of soaking time (1, 3 and 5 h) on the preparation of poly(ε-caprolactone) (PCL, 50 kDa) scaffolds by sc-foaming was evaluated by a combined X-ray microtomography (μ-CT) and mercury intrusion porosimetry (MIP) 3D-morphological analysis. Mechanical tests and in silico modelling for cell penetration and water permeability of the scaffolds were also conducted. Results evidenced the relevance of μ-CT and MIP as a synergistic analytical duo to fully elucidate the morphology of the sc-foamed scaffolds and the soaking time effect.
DOI: 10.15480/882.2957
ISSN: 0896-8446
Journal: The journal of supercritical fluids 
Institute: Thermische Verfahrenstechnik V-8 
Document Type: Article
Project: Advanced Engineering and Research of aeroGels for Environment and Life Sciences 
More Funding information: This research was funded by Xunta de Galicia [ED431F 2016/010],MCIUN [RTI2018-094131-A-I00], Agrupación Estratégica de Mate-riales [AeMAT-BIOMEDCO2, ED431E 2018/08], Agencia Estatalde Investigación [AEI] and FEDER funds.
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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