Please use this identifier to cite or link to this item:
https://doi.org/10.15480/882.3230
Title: | IVOCT catheter tracking and targeted drug delivery using magnetic particle imaging and magnetic particle navigation | Language: | English | Authors: | Griese, Florian ![]() |
Keywords: | Magnetic Particle Imaging (MPI); Magnetic Particle Navigation (MPN); intravascular optical coherence tomography (IVOCT); Catheter Tracking; Bifurcation; Target Drug Delivery | Issue Date: | 2020 | Examination Date: | 17-Dec-2020 | Source: | Technische Universität Hamburg (2020) | Abstract (german): | Magnetic-Particle-Imaging (MPI) visualisiert die quantitative Verteilung von magnetischen Nanopartikeln mit statischen und oszillierenden Magnetfeldern. In dieser Arbeit wird eine submillimetergenaue Lokalisierungsmethode entwickelt, um Markierungen für die Registrierung von MRT- und MPI-Volumen zu identifizieren. Mit dieser Methode wird auch ein IVOCT-Katheter in 4D bimodal mit MPI verfolgt. Des Weiteren werden Magnetic-Particle-Imaging und Magnetic-Particle-Navigation verwendet, um magnetische Partikel durch eine Verzweigung zu navigieren. Zuletzt wird die easy-axis-Orientierung von Proben mit dem neuartigen easy-axis-aligned-MPI-Kontrast bestimmt. |
Abstract (english): | The modality Magnetic Particle Imaging (MPI) visualizes the quantitative distribution of magnetic nanoparticles by using static and oscillating magnetic fields. In this work, a submillimeter-accurate localization method is developed to identify fiducial markers more precisely for the registration of MRI and MPI volumes. With this method a IVOCT catheter is also tracked in 4D for bimodal imaging of IVOCT and MPI. Further, the method of Magnetic Particle Imaging and Magnetic Particle Navigation is used to navigate magnetic particles through a bifurcation within a vascular flow. Finally, the novel easy-axis aligned MPI contrast is used to determine the easy-axis orientation of samples. |
URI: | http://hdl.handle.net/11420/8369 | DOI: | 10.15480/882.3230 | Institute: | Biomedizinische Bildgebung E-5 | Document Type: | Thesis | Thesis Type: | Doctoral Thesis | Advisor: | Knopp, Tobias | Referee: | Schlaefer, Alexander | Project: | Ganzkörper Magnetic-Particle-Imaging Messsequenzen Modellbasierte Parameteridentifikation in Magnetic Particle Imaging |
License: | ![]() |
Is supplemented by: | 10.5281/zenodo.3554935 |
Appears in Collections: | Publications with fulltext |
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2020PhDGrieseTORE.pdf | 150,72 MB | Adobe PDF | View/Open![]() |
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