Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.3230
Title: IVOCT catheter tracking and targeted drug delivery using magnetic particle imaging and magnetic particle navigation
Language: English
Authors: Griese, Florian  
Keywords: Magnetic Particle Imaging (MPI);Magnetic Particle Navigation (MPN);intravascular optical coherence tomography (IVOCT);Catheter Tracking;Bifurcation;Target Drug Delivery
Issue Date: 2020
Examination Date: 17-Dec-2020
Is supplemented by: 10.5281/zenodo.3554935
Abstract (german): 
Magnetic-Particle-Imaging (MPI) visualisiert die quantitative Verteilung von magnetischen Nanopartikeln mit statischen und oszillierenden Magnetfeldern. In dieser Arbeit wird eine submillimetergenaue Lokalisierungsmethode entwickelt, um Markierungen für die Registrierung von MRT- und MPI-Volumen zu identifizieren. Mit dieser Methode wird auch ein IVOCT-Katheter in 4D bimodal mit MPI verfolgt. Des Weiteren werden Magnetic-Particle-Imaging und Magnetic-Particle-Navigation verwendet, um magnetische Partikel durch eine Verzweigung zu navigieren. Zuletzt wird die easy-axis-Orientierung von Proben mit dem neuartigen easy-axis-aligned-MPI-Kontrast bestimmt.
Abstract (english): 
The modality Magnetic Particle Imaging (MPI) visualizes the quantitative distribution of magnetic nanoparticles by using static and oscillating magnetic fields. In this work, a submillimeter-accurate localization method is developed to identify fiducial markers more precisely for the registration of MRI and MPI volumes. With this method a IVOCT catheter is also tracked in 4D for bimodal imaging of IVOCT and MPI. Further, the method of Magnetic Particle Imaging and Magnetic Particle Navigation is used to navigate
magnetic particles through a bifurcation within a vascular flow. Finally, the novel easy-axis aligned MPI contrast is used to determine the easy-axis orientation of samples.
URI: http://hdl.handle.net/11420/8369
DOI: 10.15480/882.3230
Institute: Biomedizinische Bildgebung E-5 
Document Type: Thesis
Thesis Type: Doctoral Thesis
Advisor: Knopp, Tobias 
Referee: Schlaefer, Alexander 
Project: Ganzkörper Magnetic-Particle-Imaging Messsequenzen 
Modellbasierte Parameteridentifikation in Magnetic Particle Imaging 
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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