Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.3259
Publisher DOI: 10.1038/s41598-020-64280-1
Title: Visualization of spatial and temporal temperature distributions with magnetic particle imaging for liver tumor ablation therapy
Language: English
Authors: Salamon, Johannes 
Dieckhoff, Jan Henrik 
Kaul, Michael 
Jung, Caroline 
Adam, Gerhard 
Möddel, Martin  
Knopp, Tobias 
Draack, Sebastian 
Ludwig, Frank 
Ittrich, Harald 
Issue Date: 4-May-2020
Source: Scientific Reports 1 (10): 7480 (2020-12-01)
Journal: Scientific reports 
Abstract (english): 
Temperature-resolved magnetic particle imaging (MPI) represents a promising tool for medical imaging applications. In this study an approach based on a single calibration measurement was applied for highlighting the potential of MPI for monitoring of temperatures during thermal ablation of liver tumors. For this purpose, liver tissue and liver tumor phantoms embedding different superparamagnetic iron oxide nanoparticles (SPION) were prepared, locally heated up to 70 °C and recorded with MPI. Optimal temperature MPI SPIONs and a corresponding linear model for temperature calculation were determined. The temporal and spatial temperature distributions were compared with infrared (IR) camera results yielding quantitative agreements with a mean absolute deviation of 1 °C despite mismatches in boundary areas.
URI: http://hdl.handle.net/11420/8483
DOI: 10.15480/882.3259
ISSN: 2045-2322
Institute: Biomedizinische Bildgebung E-5 
Document Type: Article
More Funding information: The authors acknowledge financial support by the Deutsche Forschungsgemeinschaft (DFG) within the collaborative research center (SFB) 841 and priority program (SPP) 1681 (LU800/4–3 and VI892/1–1), the DFG grant (KN 1108/2–1) and the grant (05M16GKA) of the Bundesministerium für Bildung und Forschung (BMBF).
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
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