Publisher DOI: 10.1002/cjce.23967
Title: Process design of a continuous biotransformation with in situ product removal by cloud point extraction
Language: English
Authors: Fellechner, Oliver 
Smirnova, Irina  
Issue Date: May-2021
Publisher: Soc.
Source: The Canadian Journal of Chemical Engineering 99 (5): 1035-1049 (2021-05)
Abstract (english): 
In this work, a continuous, heterogeneous extractive biocatalysis was realized with penicillin G hydrolysis as a model reaction. Therefore, commercially available structured packing CY from Sulzer were coated with enzyme‐containing gels and their catalytic activity was examined. Thereby, the potential of aqueous micellar two‐phase systems (ATPMS) as an extraction medium was evaluated. Triton X‐114 was used as model surfactant. It was found that the separation efficiency of the packing is not affected by the coating and ATPMS allows for a good separation yield. With these results, different process concepts for the continuous, heterogeneous extractive biocatalysis were compared.
ISSN: 0008-4034
Journal: The Canadian journal of chemical engineering 
Institute: Thermische Verfahrenstechnik V-8 
Document Type: Article
Project: Gemischte mizellare Systeme in kontinuierlichen Gegenstromextraktionskolonnen für biokatalysierte reaktive Trennung 
Funded by: Deutsche Forschungsgemeinschaft (DFG) 
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