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Process design of a continuous biotransformation with in situ product removal by cloud point extraction
Publikationstyp
Journal Article
Date Issued
2021-05
Sprache
English
Author(s)
Fellechner, Oliver
Institut
TORE-URI
Volume
99
Issue
5
Start Page
1035
End Page
1049
Citation
The Canadian Journal of Chemical Engineering 99 (5): 1035-1049 (2021-05)
Publisher DOI
Scopus ID
Publisher
Soc.
In this work, a continuous, heterogeneous extractive biocatalysis was realized with penicillin G hydrolysis as a model reaction. Therefore, commercially available structured packing CY from Sulzer were coated with enzyme‐containing gels and their catalytic activity was examined. Thereby, the potential of aqueous micellar two‐phase systems (ATPMS) as an extraction medium was evaluated. Triton X‐114 was used as model surfactant. It was found that the separation efficiency of the packing is not affected by the coating and ATPMS allows for a good separation yield. With these results, different process concepts for the continuous, heterogeneous extractive biocatalysis were compared.
DDC Class
600: Technik