Publisher DOI: 10.1016/j.cep.2021.108506
Title: Evaluation of process integration for the intensification of a biotechnological process
Language: English
Authors: Meyer, Francesca 
Johannsen, Jens  
Liese, Andreas  
Fieg, Georg 
Bubenheim, Paul  
Waluga, Thomas 
Keywords: biotechnological process;mathematical model;multi-enzyme cascade;Process integration;process intensification;simulation
Issue Date: Oct-2021
Source: Chemical Engineering and Processing - Process Intensification 167: 108506 (2021-10)
Journal: Chemical engineering and processing 
Abstract (english): 
Process intensification is a well-known and established method to improve ecological and economic efficiency of large-scale chemical processes. Process intensification in form of integrating an in-situ product or intermediate removal can also improve processes. In this study the effects of integrating an intermediate separation in form of an extraction centrifuge and a product separation in form of a pre-purification into a multi-enzyme cascade as well as the potential for further process integration in form of a reactive extraction centrifuge are analyzed for a biotechnological process. In order to evaluate the application of process integration, different process configurations are compared regarding to the efficiency using a model-based approach. Although the highly integrated process leads to lower space-time yields in some cases, an operating window can be identified in which the space-time yield is significantly higher compared to a sequential process. In order to distinguish both cases and thus choose a suitable operating point simulative studies are required. Moreover, a potential for further integration can be identified for the reference process studied in this work.
ISSN: 0255-2701
Institute: Systemverfahrenstechnik V-4 
Technische Biokatalyse V-6 
Document Type: Article
Project: Multienzymkaskade im 2-Phasensystem 
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