|Publisher DOI:||10.1016/j.cep.2021.108506||Title:||Evaluation of process integration for the intensification of a biotechnological process||Language:||English||Authors:||Meyer, Francesca
|Keywords:||biotechnological process;mathematical model;multi-enzyme cascade;Process integration;process intensification;simulation||Issue Date:||Oct-2021||Source:||Chemical Engineering and Processing - Process Intensification 167: 108506 (2021-10)||Journal:||Chemical engineering and processing||Abstract (english):||
Process intensification is a well-known and established method to improve ecological and economic efficiency of large-scale chemical processes. Process intensification in form of integrating an in-situ product or intermediate removal can also improve processes. In this study the effects of integrating an intermediate separation in form of an extraction centrifuge and a product separation in form of a pre-purification into a multi-enzyme cascade as well as the potential for further process integration in form of a reactive extraction centrifuge are analyzed for a biotechnological process. In order to evaluate the application of process integration, different process configurations are compared regarding to the efficiency using a model-based approach. Although the highly integrated process leads to lower space-time yields in some cases, an operating window can be identified in which the space-time yield is significantly higher compared to a sequential process. In order to distinguish both cases and thus choose a suitable operating point simulative studies are required. Moreover, a potential for further integration can be identified for the reference process studied in this work.
Technische Biokatalyse V-6
|Document Type:||Article||Project:||Multienzymkaskade im 2-Phasensystem|
|Appears in Collections:||Publications without fulltext|
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