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    Bioimpedance spectroscopy for characterization of healthy and cancerous tissues
    Bioimpedance spectroscopy is a technique that can potentially be used to differentiate healthy from sick tissues based on the variation of electrical properties of biological material when submitted to frequency variable electric fields. In this paper, the technique was applied to measure the impedance of five different tissues of a healthy mice and two cancerous infected with the tumor lines UT-SCC-5 (tongue squamous cell carcinoma) and UM-SCC-10A (laryngeal squamous cell carcinoma). Results show that the different tissue types show a significant variation in their impedance values. More interestingly is that the two cancerous tumors have the highest conductivity values, or equivalently the lowest impedance values.
    Publicationtype: Conference Paper
      203
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    Item type:Publication,
      74
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    Item type:Publication,
    Development of an impedance spectroscopy device for on-line cell growth monitoring
    The impedance and dielectric properties of biological samples are often used to estimate the number of cells growing in a culture, and monitor the cell growth in real time. For these type of studies, high-cost and complex commercial equipment is often required. The design and implementation of a standalone device for impedance spectroscopy of cell samples is presented, featuring low cost, portability and easy reconfigurability of frequency and voltage. The device can generate sinusoidal, square and triangular signals with frequencies up to 125 kHz, at voltages in the range from 0 V to 100 mV. Cell growth experiments were carried out with yeast cultures, and the results are compared with a commercial Agilent 4284A LCR meter. The error percentages for magnitude and phase measurements are <5%.
    Publicationtype: Journal Article
      77
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    Item type:Publication, Access status: with files ,
    An impedance spectroscopy ASIC for low-frequency characterization of biological samples
    This paper describes the design and testing of an ASIC for impedance spectroscopy of biological samples at frequencies up to 40 kHz. The circuit is designed in the 350 nm AMS H35B4 technology and enables the measurement of impedances in the range of 10 kW up to 28 MW. The design features a digital oscillator and a current-to-voltage converter. The ASIC is used to monitor the growth of yeast cell cultures and porcine chondrocytes, in real-time, using a standard 384-well plate and copper electrodes.
    Publicationtype: Conference Paper
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