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Item type:Publication, Access status: without files , Bioresorption and degradation of biomaterialsThe human body is a composite structure, completely constructed of biodegradable materials. This allows the cells of the body to remove and replace old or defective tissue with new material. Consequently, artificial resorbable biomaterials have been developed for application in regenerative medicine. We discuss here advantages and disadvantages of these bioresorbable materials for medical applications and give an overview of typically used metals, ceramics and polymers. Methods for the quantification of bioresorption in vitro and in vivo are described. The next challenge will be to better understand the interface between cell and material and to use this knowledge for the design of " intelligent" materials that can instruct the cells to build specific tissue geometries and degrade in the process.Publicationtype: Journal Article5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Advances in porous biomaterials for dental and orthopaedic applications(Multidisciplinary Digital Publishing Institute (MDPI), 2010-04-28); ; ; ; The connective hard tissues bone and teeth are highly porous on a micrometer scale, but show high values of compression strength at a relatively low weight. The fabrication of porous materials has been actively researched and different processes have been developed that vary in preparation complexity and also in the type of porous material that they produce. Methodologies are available for determination of pore properties. The purpose of the paper is to give an overview of these methods, the role of porosity in natural porous materials and the effect of pore properties on the living tissues. The minimum pore size required to allow the ingrowth of mineralized tissue seems to be in the order of 50 μm: larger pore sizes seem to improve speed and depth of penetration of mineralized tissues into the biomaterial, but on the other hand impair the mechanical properties. The optimal pore size is therefore dependent on the application and the used material.Publicationtype: Review ArticleScopus© Citations 171 250 384