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    Item type:Publication, Access status: with files ,
    Development of a system for fast identification and characterization of biological cells
    (2023)
    Silva Teixeira, Viviane
    ;
    Krautschneider, Wolfgang
    Bio Impedance Spectroscopy (BIS) is the application of a signal with varying frequency to a biological material and measuring its frequency response. This research explores BIS to distinguish cancer and healthy cells and tissues, and also metastatic from non-metastatic cancers. The first important finding is one physical characteristic that distinguishes metastatic from non-metastatic cancer cells: the cell surface charge. For all researched cancer groups the cell surface charge per area was found to be smaller for more metastatic cancers than for less metastatic ones. Another finding was that cancer tissues in general have a lower impedance magnitude than healthy ones. An important conclusion is that healthy and cancer tissues and cells show a different spectral behavior, which is close correlated to the effects of the cancer in the healthy cells and tissues.
    Publicationtype: Doctoral Thesis
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    Item type:Publication, Access status: with files ,
    Use of electrical impedance spectroscopy to distinguish cancer from normal tissues with a four electrode terminal setup
    (De Gruyter, 2020-11-26)
    Silva Teixeira, Viviane
    ;
    Labitzky, Vera
    ;
    Schumacher, Udo
    ;
    Krautschneider, Wolfgang
    Cancer and normal tissues are visually different from each other, especially so in more advanced cancer stages. More important, they are not only visually contrasting, but if an electric field is applied to both tissue types and the frequency is varied in a wide range, it will be seen that the two tissue types in general have a spectral response divergent from each other and this has to do with the characteristics of cancer tissues in contrast to normal ones. In this work, Electrical Impedance Spectroscopy is applied to try to distinguish cancer from healthy tissues by means of their impedance spectrum using a four-electrode-terminal setup. The use of the fourterminal- setup setup is important to circumvent the impact of electrode polarization at frequencies below 1 kHz.
    Publicationtype: Journal Article
    Scopus© Citations 5  179  204