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Item type:Publication, Access status: without files , Combinatorial Particle Patterning(2017-11-10); ; ; The unique properties of solid particles make them a promising element of micro- and nanostructure technologies. Solid particles can be used as building blocks for micro and nanostructures, carriers of monomers, or catalysts. The possibility of patterning different kinds of particles on the same substrate opens the pathway for novel combinatorial designs and novel technologies. One of the examples of such technologies is the synthesis of peptide arrays with amino acid particles. This review examines the known methods of combinatorial particle patterning via static electrical and magnetic fields, laser radiation, patterning by synthesis, and particle patterning via chemically modified or microstructured surfaces.Publicationtype: Review Article5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Selective Functionalization of Microstructured Surfaces by Laser-Assisted Particle TransferMicrocavity arrays represent millions of different reaction compartments to screen, for example, molecular interactions, exogenous factors for cells or enzymatic activity. A novel method is presented to selectively synthesize different compounds in arrays of microcavities with up to 1 000 000 cavities per cm<sup>2</sup>. In this approach, polymer microparticles with embedded pre-activated monomers are selectively transferred into microcavities with laser radiation. After particle patterning, heating of the particle matrix simultaneously leads to diffusion and coupling of the monomers inside each microcavity separately. This method exhibits flexibility, not only in the choice of compounds, but also in the choice of particle matrix material, which determines the chemical reaction environment. The laser-assisted selective functionalization of microcavities can be easily combined with the intensively growing number of laser applications for patterning of molecules and cells, which is useful for the development of novel biological assays.Publicationtype: Journal Article1