Computational model of gastric motility with active-strain electromechanics

We present an electro-mechanical constitutive framework for the modeling of gastric motility, including pacemaker electrophysiology and smooth muscle contractility. In this framework, we adopt a phenomenological description of the gastric tissue. Tissue electrophysiology is represented by a set of two minimal two-variable models and tissue electromechanics by an active-strain finite elasticity approach. We numerically investigate the implication of the spatial distribution of pacemaker cells on the entrainment and synchronization of the slow waves characterizing gastric motility in health and disease. On simple schematic model geometries, we demonstrate that the proposed computational framework is amenable to large scale in-silico analyses of the complex gastric motility including the underlying electro-mechanical coupling.

Subjects

active-strain electro-mechanics

electrophysiology

finite elasticity

gastric motility

DDC Class

600: Technik

Lizenz

https://creativecommons.org/licenses/by/4.0/

Name

Brandstaeter_et_al-2018-ZAMM.pdf

Size

2.88 MB

Format

Adobe PDF

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Computational model of gastric motility with active-strain electromechanics