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  4. Label-free photonic biosensors fabricated with low-loss hydrogenated amorphous silicon resonators
 
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Label-free photonic biosensors fabricated with low-loss hydrogenated amorphous silicon resonators

Citation Link: https://doi.org/10.15480/882.1999
Publikationstyp
Journal Article
Date Issued
2013-11-05
Sprache
English
Author(s)
Lipka, Timo  
Wahn, Lennart  
Trieu, Hoc Khiem  
Hilterhaus, Lutz  
Müller, Jörg  
Institut
Mikrosystemtechnik E-7  
Technische Biokatalyse V-6  
TORE-DOI
10.15480/882.1999
TORE-URI
https://tubdok.tub.tuhh.de/handle/11420/2002
Journal
Journal of Nanophotonics  
Volume
7
Issue
1
Start Page
073793
Citation
Journal of nanophotonics 1 (7): 073793 (2013)
Publisher DOI
10.1117/1.JNP.7.073793
Scopus ID
2-s2.0-84888192596
Publisher
SPIE
The precise detection of chemicals and biomolecules is of great interest in the areas of biotechnology and medical diagnostics. Thus, there is a need for highly sensitive, small area, andlow-cost sensors. We fabricated and optically characterized hydrogenated amorphous silicon photonic resonators for label-free lab-on-chip biosensors. The sensing was performed with small-footprint microdisk and microring resonators that detect a refractive-index change via the evanescent electric field. Homogeneous sensing with NaCl and surface-sensing experiments with immobilized bovine serum albumin (BSA) were carried out. A sensitivity as high as 460 nm/RIU was measured for NaCl dissolved in deionized water for the disk, whereas about 50 nm/RIU was determined for the ring resonator. The intrinsic limits of detection were calculated to be 3.3 × 10-4 and 3.2 × 10-3 at 1550-nm wavelength. We measured the binding of BSA to functionalized ring resonators and found that molecular masses can be detected down to the clinically relevant femtogram regime. The detection and quantification of related analytes with hydrogenated amorphous silicon photonic sensors can be used in medical healthcare diagnostics like point-of-care-testing and biotechnological screening.
Subjects
amorphous silicon
a-Si
H
photonics
microring
microdisk
resonator
label-free biosensor
lab-on-chip
point-of-care diagnostics
DDC Class
530: Physik
570: Biowissenschaften, Biologie
Funding(s)
Biosensor auf Basis integrierter Photonik  
Publication version
publishedVersion
Lizenz
https://creativecommons.org/licenses/by/3.0/
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