Please use this identifier to cite or link to this item:
Publisher DOI: 10.1016/j.actbio.2021.07.054
arXiv ID: 2104.05580v1
Title: What do cells regulate in soft tissues on short time scales?
Language: English
Authors: Eichinger, Jonas 
Paukner, Daniel 
Aydin, Roland C. 
Wall, Wolfgang A. 
Humphrey, Jay Dowell 
Cyron, Christian J. 
Keywords: Cell-matrix interactions; Discrete fiber model; Homeostasis; Mechanoregulation; Mechanosensing; Quantitative Biology - Cell Behavior; Quantitative Biology - Cell Behavior; Computer Science - Computational Engineering; Finance; and Science
Issue Date: 28-Jul-2021
Publisher: Elsevier
Source: Acta Biomaterialia 134: 348-356 (2021-04-09)
Abstract (english): 
Cells within living soft biological tissues seem to promote the maintenance of a mechanical state within a defined range near a so-called set-point. This mechanobiological process is often referred to as mechanical homeostasis. During this process, cells intimately interact with the fibers of the surrounding extracellular matrix (ECM). It remains poorly understood, however, what individual cells actually regulate during these interactions, and how these micromechanical regulations are translated to tissue level to lead to what we macroscopically call mechanical homeostasis. Herein, we examine this question by a combination of experiments, theoretical analysis and computational modeling. We demonstrate that on short time scales (hours) - during which deposition and degradation of ECM fibers can largely be neglected - cells appear to regulate neither the stress / strain in the ECM nor their own shape, but rather only the contractile forces that they exert on the surrounding ECM.
DOI: 10.15480/882.3873
ISSN: 1878-7568
Institute: Kontinuums- und Werkstoffmechanik M-15 
Document Type: Article
Project: Vaskuläre Wachstums- und Umbildungsprozesse in Aneurysmen 
Experimentelle Untersuchung und mathematische Modellierung mechanisch gesteuerter Wachstums- und Umbauprozesse in postpubertären Schweineharnblasen 
Funded by: Deutsche Forschungsgemeinschaft (DFG) 
More Funding information: The authors gratefully ac- knowledge financial support by the International Graduate School of Science and Engineering (IGSSE) of Technical University of Mu- nich, Germany.
License: CC BY 4.0 (Attribution) CC BY 4.0 (Attribution)
Appears in Collections:Publications with fulltext

Files in This Item:
File Description SizeFormat
1-s2.0-S174270612100492X-main.pdfVerlags-PDF2,61 MBAdobe PDFView/Open
Show full item record

Page view(s)

Last Week
Last month
checked on May 29, 2023


checked on May 29, 2023


Last Week
Last month
checked on Jun 30, 2022

PubMed Central

Last Week
Last month
checked on May 30, 2023

Google ScholarTM


Note about this record

Cite this record


This item is licensed under a Creative Commons License Creative Commons