Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.1768
DC FieldValueLanguage
dc.contributor.authorGräser, Matthias-
dc.contributor.authorKnopp, Tobias-
dc.contributor.authorSzwargulski, Patryk-
dc.contributor.authorFriedrich, Thomas-
dc.contributor.authorGladiß, Anselm von-
dc.contributor.authorKaul, Michael-
dc.contributor.authorKrishnan, Kannan M.-
dc.contributor.authorIttrich, Harald-
dc.contributor.authorAdam, Gerhard-
dc.contributor.authorBuzug, Thorsten M.-
dc.date.accessioned2018-11-06T14:26:57Z-
dc.date.available2018-11-06T14:26:57Z-
dc.date.issued2017-07-31-
dc.identifier.citationScientific Reports 1 (7): - (2017)de_DE
dc.identifier.issn2045-2322de_DE
dc.identifier.urihttp://tubdok.tub.tuhh.de/handle/11420/1771-
dc.description.abstractSuperparamagnetic iron-oxide nanoparticles can be used in medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The two main strengths of MPI are high temporal resolution and high sensitivity. While the first has been proven in the assessment of dynamic processes like cardiac imaging, it is unknown how far the detection limit of MPI can be lowered. Within this work, we will present a highly sensitive gradiometric receive-coil unit combined with a noise-matching network tailored for the imaging of mice. The setup is capable of detecting 5 ng of iron in-vitro with an acquisition time of 2.14 sec. In terms of iron concentration we are able to detect 156 μg/L marking the lowest value that has been reported for an MPI scanner so far. In-vivo MPI mouse images of a 512 ng bolus and a 21.5 ms acquisition time allow for capturing the flow of an intravenously injected tracer through the heart of a mouse. Since it has been rather difficult to compare detection limits across MPI publications we propose guidelines to improve the comparability of future MPI studies.en
dc.description.sponsorshipSupport of the German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) (Grant Numbers BU 1436/10-1 and 13GW0069A), German Research Foundation (DFG, grant numbers KN 1108/2-1 and AD 125/5-1). Work at UW was supported by NIH grant R42 EB013520-02A1.de_DE
dc.language.isoende_DE
dc.publisherNature Publishing Groupde_DE
dc.relation.ispartofScientific reportsde_DE
dc.rightsCC BY 4.0de_DE
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.subjectmagnetic particle imagingde_DE
dc.subjectMPIde_DE
dc.subjectintravenously injected tracerde_DE
dc.subject.ddc530: Physikde_DE
dc.subject.ddc610: Medizinde_DE
dc.titleTowards picogram detection of superparamagnetic iron-oxide particles using a gradiometric receive coilde_DE
dc.typeArticlede_DE
dc.identifier.urnurn:nbn:de:gbv:830-88222950-
dc.identifier.doi10.15480/882.1768-
dc.type.diniarticle-
dc.subject.ddccode610-
dc.subject.ddccode530-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-88222950de_DE
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dc.identifier.hdl11420/1771-
tuhh.abstract.englishSuperparamagnetic iron-oxide nanoparticles can be used in medical applications like vascular or targeted imaging. Magnetic particle imaging (MPI) is a promising tomographic imaging technique that allows visualizing the 3D nanoparticle distribution concentration in a non-invasive manner. The two main strengths of MPI are high temporal resolution and high sensitivity. While the first has been proven in the assessment of dynamic processes like cardiac imaging, it is unknown how far the detection limit of MPI can be lowered. Within this work, we will present a highly sensitive gradiometric receive-coil unit combined with a noise-matching network tailored for the imaging of mice. The setup is capable of detecting 5 ng of iron in-vitro with an acquisition time of 2.14 sec. In terms of iron concentration we are able to detect 156 μg/L marking the lowest value that has been reported for an MPI scanner so far. In-vivo MPI mouse images of a 512 ng bolus and a 21.5 ms acquisition time allow for capturing the flow of an intravenously injected tracer through the heart of a mouse. Since it has been rather difficult to compare detection limits across MPI publications we propose guidelines to improve the comparability of future MPI studies.de_DE
tuhh.publisher.doi10.1038/s41598-017-06992-5-
tuhh.publication.instituteBiomedizinische Bildgebung E-5de_DE
tuhh.identifier.doi10.15480/882.1768-
tuhh.type.opus(wissenschaftlicher) Artikelde
tuhh.institute.germanBiomedizinische Bildgebung E-5de
tuhh.institute.englishBiomedizinische Bildgebung E-5de_DE
tuhh.gvk.hasppnfalse-
tuhh.hasurnfalse-
openaire.rightsinfo:eu-repo/semantics/openAccessde_DE
dc.type.driverarticle-
dc.rights.ccbyde_DE
dc.rights.ccversion4.0de_DE
dc.type.casraiJournal Articleen
tuhh.container.issue1de_DE
tuhh.container.volume7de_DE
tuhh.container.startpageArticle number: 6872de_DE
dc.rights.nationallicensefalsede_DE
item.fulltextWith Fulltext-
item.creatorOrcidGräser, Matthias-
item.creatorOrcidKnopp, Tobias-
item.creatorOrcidSzwargulski, Patryk-
item.creatorOrcidFriedrich, Thomas-
item.creatorOrcidGladiß, Anselm von-
item.creatorOrcidKaul, Michael-
item.creatorOrcidKrishnan, Kannan M.-
item.creatorOrcidIttrich, Harald-
item.creatorOrcidAdam, Gerhard-
item.creatorOrcidBuzug, Thorsten M.-
item.grantfulltextopen-
item.languageiso639-1other-
item.creatorGNDGräser, Matthias-
item.creatorGNDKnopp, Tobias-
item.creatorGNDSzwargulski, Patryk-
item.creatorGNDFriedrich, Thomas-
item.creatorGNDGladiß, Anselm von-
item.creatorGNDKaul, Michael-
item.creatorGNDKrishnan, Kannan M.-
item.creatorGNDIttrich, Harald-
item.creatorGNDAdam, Gerhard-
item.creatorGNDBuzug, Thorsten M.-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.deptBiomedizinische Bildgebung E-5-
crisitem.author.orcid0000-0003-1472-5988-
crisitem.author.orcid0000-0002-1589-8517-
crisitem.author.orcid0000-0003-2563-9006-
crisitem.author.orcid0000-0003-1340-4576-
crisitem.author.orcid0000-0002-0399-8043-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
crisitem.author.parentorgStudiendekanat Elektrotechnik, Informatik und Mathematik-
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