DC FieldValueLanguage
dc.contributor.authorMitrev, Yavor N.-
dc.contributor.authorMehandzhiyski, Aleksander Y.-
dc.contributor.authorBatovska, Daniela I.-
dc.contributor.authorLiese, Andreas-
dc.contributor.authorGalunsky, Boris-
dc.date.accessioned2019-08-01T08:53:48Z-
dc.date.available2019-08-01T08:53:48Z-
dc.date.issued2016-
dc.identifier.citationJournal of the Serbian Chemical Society 11 (81): 1231-1237 (2016)de_DE
dc.identifier.issn1820-7421de_DE
dc.identifier.urihttp://hdl.handle.net/11420/3043-
dc.description.abstractAn E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (EC 3.5.1.14) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (EC 3.5.1.81) also catalyzed the reaction between acetophenone and p-nitrobenzaldehyde. Such a "green" approach to the synthesis of chalcones is of great interest because of the important applications of chalcones as formula ingredients in the pharmaceutical, food and cosmetic industries.en
dc.language.isoende_DE
dc.publisherSoc.de_DE
dc.relation.ispartofJournal of the Serbian Chemical Societyde_DE
dc.subject.ddc540: Chemiede_DE
dc.subject.ddc620: Ingenieurwissenschaftende_DE
dc.titleOriginal enzyme-catalyzed synthesis of chalcones: utilization of hydrolase promiscuityde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dc.subject.ddccode620-
dc.subject.ddccode540-
dcterms.DCMITypeText-
tuhh.abstract.englishAn E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (EC 3.5.1.14) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (EC 3.5.1.81) also catalyzed the reaction between acetophenone and p-nitrobenzaldehyde. Such a "green" approach to the synthesis of chalcones is of great interest because of the important applications of chalcones as formula ingredients in the pharmaceutical, food and cosmetic industries.de_DE
tuhh.publisher.doi10.2298/JSC160422069M-
tuhh.publication.instituteTechnische Biokatalyse V-6de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
tuhh.institute.germanTechnische Biokatalyse V-6de
tuhh.institute.englishTechnische Biokatalyse V-6de_DE
tuhh.gvk.hasppnfalse-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.issue11de_DE
tuhh.container.volume81de_DE
tuhh.container.startpage1231de_DE
tuhh.container.endpage1237de_DE
item.grantfulltextnone-
item.creatorGNDMitrev, Yavor N.-
item.creatorGNDMehandzhiyski, Aleksander Y.-
item.creatorGNDBatovska, Daniela I.-
item.creatorGNDLiese, Andreas-
item.creatorGNDGalunsky, Boris-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.creatorOrcidMitrev, Yavor N.-
item.creatorOrcidMehandzhiyski, Aleksander Y.-
item.creatorOrcidBatovska, Daniela I.-
item.creatorOrcidLiese, Andreas-
item.creatorOrcidGalunsky, Boris-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.deptTechnische Biokatalyse V-6-
crisitem.author.orcid0000-0001-5671-4545-
crisitem.author.orcid0000-0002-4867-9935-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
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