|Publisher DOI:||10.2298/JSC160422069M||Title:||Original enzyme-catalyzed synthesis of chalcones: utilization of hydrolase promiscuity||Language:||English||Authors:||Mitrev, Yavor N.
Mehandzhiyski, Aleksander Y.
Batovska, Daniela I.
|Issue Date:||2016||Publisher:||Soc.||Source:||Journal of the Serbian Chemical Society 11 (81): 1231-1237 (2016)||Journal or Series Name:||Journal of the Serbian Chemical Society||Abstract (english):||An E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (EC 188.8.131.52) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (EC 184.108.40.206) also catalyzed the reaction between acetophenone and p-nitrobenzaldehyde. Such a "green" approach to the synthesis of chalcones is of great interest because of the important applications of chalcones as formula ingredients in the pharmaceutical, food and cosmetic industries.||URI:||http://hdl.handle.net/11420/3043||ISSN:||1820-7421||Institute:||Technische Biokatalyse V-6||Type:||(wissenschaftlicher) Artikel|
|Appears in Collections:||Publications without fulltext|
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