DC FieldValueLanguage
dc.contributor.authorSubrahmanyam, Raman-
dc.contributor.authorKeil, Claudia-
dc.contributor.authorDieringer, Paul-
dc.contributor.authorHübner, Christopher-
dc.contributor.authorBueno, Alberto-
dc.contributor.authorGurikov, Pavel-
dc.contributor.authorNissen, Jörg-
dc.contributor.authorHoltkamp, Michael-
dc.contributor.authorKarst, Uwe-
dc.contributor.authorHaase, Hajo-
dc.contributor.authorSmirnova, Irina-
dc.date.accessioned2019-08-19T13:37:18Z-
dc.date.available2019-08-19T13:37:18Z-
dc.date.issued2019-11-
dc.identifier.citationJournal of Supercritical Fluids (153): 104545 (2019-11)de_DE
dc.identifier.issn0896-8446de_DE
dc.identifier.urihttp://hdl.handle.net/11420/3133-
dc.description.abstractCalcium-alginate aerogels augmented with zinc and silver can provide the next generation superabsorbent medical devices for advanced wound care with high cell and tissue tolerability and controlled compound release rates during wound healing. In this study, we addressed the fabrication and metal detection of alginate-based aerogels with these immunoactive cations. All three cations were incorporated into the alginate aerogel, albeit in different quantities, due to different magnitudes of leaching during solvent exchange step; an effect not reported previously. Silver addition led to an increase in aerogel zinc content without influencing calcium incorporation. All three metal ions were released into supernatants upon swelling aerogels in aqueous solutions, comparable to those measured for common wound dressings in human and animal injury models. The in vitro bioactivity studies showed that Zn-enriched swelling supernatants were able to suppress NO production in stimulated RAW 264.7 macrophages, indicating an effective anti-inflammatory activity.en
dc.description.sponsorshipFinancial support from DFG (project SM 82/13-1) is gratefully acknowledged.de_DE
dc.language.isoende_DE
dc.relation.ispartofThe journal of supercritical fluidsde_DE
dc.titleAlginate aerogels carrying calcium, zinc and silver cations for wound care: Fabrication and metal detectionde_DE
dc.typeArticlede_DE
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.abstract.englishCalcium-alginate aerogels augmented with zinc and silver can provide the next generation superabsorbent medical devices for advanced wound care with high cell and tissue tolerability and controlled compound release rates during wound healing. In this study, we addressed the fabrication and metal detection of alginate-based aerogels with these immunoactive cations. All three cations were incorporated into the alginate aerogel, albeit in different quantities, due to different magnitudes of leaching during solvent exchange step; an effect not reported previously. Silver addition led to an increase in aerogel zinc content without influencing calcium incorporation. All three metal ions were released into supernatants upon swelling aerogels in aqueous solutions, comparable to those measured for common wound dressings in human and animal injury models. The in vitro bioactivity studies showed that Zn-enriched swelling supernatants were able to suppress NO production in stimulated RAW 264.7 macrophages, indicating an effective anti-inflammatory activity.de_DE
tuhh.publisher.doi10.1016/j.supflu.2019.104545-
tuhh.publication.instituteThermische Verfahrenstechnik V-8de_DE
tuhh.publication.instituteEntwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2de_DE
tuhh.type.opus(wissenschaftlicher) Artikel-
tuhh.institute.germanThermische Verfahrenstechnik V-8de
tuhh.institute.englishThermische Verfahrenstechnik V-8de_DE
tuhh.gvk.hasppnfalse-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.volume153de_DE
tuhh.container.articlenumber104545de_DE
item.creatorGNDSubrahmanyam, Raman-
item.creatorGNDKeil, Claudia-
item.creatorGNDDieringer, Paul-
item.creatorGNDHübner, Christopher-
item.creatorGNDBueno, Alberto-
item.creatorGNDGurikov, Pavel-
item.creatorGNDNissen, Jörg-
item.creatorGNDHoltkamp, Michael-
item.creatorGNDKarst, Uwe-
item.creatorGNDHaase, Hajo-
item.creatorGNDSmirnova, Irina-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.grantfulltextnone-
item.creatorOrcidSubrahmanyam, Raman-
item.creatorOrcidKeil, Claudia-
item.creatorOrcidDieringer, Paul-
item.creatorOrcidHübner, Christopher-
item.creatorOrcidBueno, Alberto-
item.creatorOrcidGurikov, Pavel-
item.creatorOrcidNissen, Jörg-
item.creatorOrcidHoltkamp, Michael-
item.creatorOrcidKarst, Uwe-
item.creatorOrcidHaase, Hajo-
item.creatorOrcidSmirnova, Irina-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptEntwicklung und Modellierung neuartiger nanoporöser Materialien V-EXK2-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.orcid0000-0003-0598-243X-
crisitem.author.orcid0000-0003-4503-4039-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik-
Appears in Collections:Publications without fulltext
Show simple item record

Page view(s)

85
Last Week
4
Last month
10
checked on Oct 28, 2020

Google ScholarTM

Check

Add Files to Item

Note about this record

Export

Items in TORE are protected by copyright, with all rights reserved, unless otherwise indicated.