Please use this identifier to cite or link to this item: https://doi.org/10.15480/882.2957
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dc.contributor.authorSantos-Rosales, Víctor-
dc.contributor.authorGallo, Marta-
dc.contributor.authorJaeger, Philip-
dc.contributor.authorAlvarez-Lorenzo, Carmen-
dc.contributor.authorGómez-Amoza, José Luis-
dc.contributor.authorGarcía-González, Carlos A.-
dc.date.accessioned2020-10-01T07:32:34Z-
dc.date.available2020-10-01T07:32:34Z-
dc.date.issued2020-08-07-
dc.identifier.citationJournal of Supercritical Fluids (166): 105012 (2020-12-01)de_DE
dc.identifier.issn0896-8446de_DE
dc.identifier.urihttp://hdl.handle.net/11420/7445-
dc.description.abstractHierarchically porous synthetic bone grafts (scaffolds) are gaining attention in the clinical arena. Scaffolds should combine morphological (macro- and microporosity, pore interconnectivity), mechanical and biological (biocompatibility, degradation rate) properties to fit this specific use. Supercritical (sc-) foaming is a versatile scaffold processing technology. However, the selection of the optimum operating conditions to obtain a defined scaffold structure is hampered by the lack of a single characterization technique able to fully elucidate the porous features of the resulting scaffolds. In this work, the effect of soaking time (1, 3 and 5 h) on the preparation of poly(ε-caprolactone) (PCL, 50 kDa) scaffolds by sc-foaming was evaluated by a combined X-ray microtomography (μ-CT) and mercury intrusion porosimetry (MIP) 3D-morphological analysis. Mechanical tests and in silico modelling for cell penetration and water permeability of the scaffolds were also conducted. Results evidenced the relevance of μ-CT and MIP as a synergistic analytical duo to fully elucidate the morphology of the sc-foamed scaffolds and the soaking time effect.en
dc.language.isoende_DE
dc.publisherElsevier Sciencede_DE
dc.relation.ispartofThe journal of supercritical fluidsde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/de_DE
dc.subject3D-biodegradable scaffoldsde_DE
dc.subject3D-modellingde_DE
dc.subjectBone regenerationde_DE
dc.subjectPore interconnectivityde_DE
dc.subjectSupercritical foamingde_DE
dc.subjectX-ray microtomographyde_DE
dc.subject.ddc600: Technikde_DE
dc.titleNew insights in the morphological characterization and modelling of poly(ε-caprolactone) bone scaffolds obtained by supercritical CO₂ foamingde_DE
dc.typeArticlede_DE
dc.identifier.doi10.15480/882.2957-
dc.type.diniarticle-
dcterms.DCMITypeText-
tuhh.identifier.urnurn:nbn:de:gbv:830-882.0107227-
tuhh.oai.showtruede_DE
tuhh.abstract.englishHierarchically porous synthetic bone grafts (scaffolds) are gaining attention in the clinical arena. Scaffolds should combine morphological (macro- and microporosity, pore interconnectivity), mechanical and biological (biocompatibility, degradation rate) properties to fit this specific use. Supercritical (sc-) foaming is a versatile scaffold processing technology. However, the selection of the optimum operating conditions to obtain a defined scaffold structure is hampered by the lack of a single characterization technique able to fully elucidate the porous features of the resulting scaffolds. In this work, the effect of soaking time (1, 3 and 5 h) on the preparation of poly(ε-caprolactone) (PCL, 50 kDa) scaffolds by sc-foaming was evaluated by a combined X-ray microtomography (μ-CT) and mercury intrusion porosimetry (MIP) 3D-morphological analysis. Mechanical tests and in silico modelling for cell penetration and water permeability of the scaffolds were also conducted. Results evidenced the relevance of μ-CT and MIP as a synergistic analytical duo to fully elucidate the morphology of the sc-foamed scaffolds and the soaking time effect.de_DE
tuhh.publisher.doi10.1016/j.supflu.2020.105012-
tuhh.publication.instituteThermische Verfahrenstechnik V-8de_DE
tuhh.identifier.doi10.15480/882.2957-
tuhh.type.opus(wissenschaftlicher) Artikel-
dc.type.driverarticle-
dc.type.casraiJournal Article-
tuhh.container.volume166de_DE
dc.relation.projectAdvanced Engineering and Research of aeroGels for Environment and Life Sciencesde_DE
dc.rights.nationallicensefalsede_DE
dc.identifier.scopus2-s2.0-85089699012de_DE
tuhh.container.articlenumber105012de_DE
local.status.inpressfalsede_DE
local.type.versionpublishedVersionde_DE
local.funding.infoThis research was funded by Xunta de Galicia [ED431F 2016/010],MCIUN [RTI2018-094131-A-I00], Agrupación Estratégica de Mate-riales [AeMAT-BIOMEDCO2, ED431E 2018/08], Agencia Estatalde Investigación [AEI] and FEDER funds.de_DE
datacite.resourceTypeJournal Article-
datacite.resourceTypeGeneralText-
item.mappedtypeArticle-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.creatorOrcidSantos-Rosales, Víctor-
item.creatorOrcidGallo, Marta-
item.creatorOrcidJaeger, Philip-
item.creatorOrcidAlvarez-Lorenzo, Carmen-
item.creatorOrcidGómez-Amoza, José Luis-
item.creatorOrcidGarcía-González, Carlos A.-
item.creatorGNDSantos-Rosales, Víctor-
item.creatorGNDGallo, Marta-
item.creatorGNDJaeger, Philip-
item.creatorGNDAlvarez-Lorenzo, Carmen-
item.creatorGNDGómez-Amoza, José Luis-
item.creatorGNDGarcía-González, Carlos A.-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
crisitem.project.funderEuropean Cooperation in Science and Technology (COST)-
crisitem.project.funderid501100000921-
crisitem.project.funderrorid01bstzn19-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.deptThermische Verfahrenstechnik V-8-
crisitem.author.orcid0000-0002-6342-7314-
crisitem.author.orcid0000-0002-8546-7085-
crisitem.author.orcid0000-0001-7615-6616-
crisitem.author.orcid0000-0001-9542-3679-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik (V)-
crisitem.author.parentorgStudiendekanat Verfahrenstechnik (V)-
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