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Item type:Publication, Access status: with files , Deep learning-based 3D reconstruction of dentate nuclei in Friedreich’s ataxia from T2*weighted MR images(Elsevier, 2025-11-07); ; ; Horn, LeonDentate nucleus (DN) degeneration is a key neuropathological feature in Friedreich’s ataxia (FRDA), and its accurate quantification is critical for understanding disease progression. However, its visualization and volumetry require iron-sensitive imaging techniques and time-consuming segmentation procedures, posing challenges for conventional ML approaches due to small datasets typical of rare diseases. We present a transfer learning–based machine learning pipeline for automated DN segmentation that directly uses standard T2*-weighted Magnetic Resonance Imaging (MRI), which highlights the DN without additional processing, and is designed to perform robustly with limited annotated data. Using 38 manually labeled subjects (18 FRDA, 20 controls), the model was validated via five-fold cross-validation and an independent hold-out test set, achieving Dice scores of 0.81–0.87 and outperforming classical atlas-based methods. Pretraining improved performance by ~10% in patients and >5% in controls. Applied to 181 longitudinal scans from 33 FRDA patients and 33 controls, the model revealed significantly reduced DN volumes in FRDA, with reductions correlating with disease duration and clinical severity over time. Our approach provides a scalable and reproducible segmentation framework, requiring minimal annotated data and no preprocessing, while demonstrating robust performance across crossvalidationand independent testing. Additionally, it enables the first longitudinal volumetric analysis of DN in FRDA using standard T2*-weighted MRI, demonstrating its practical utility for monitoring neurodegenerative changes. Overall, this work illustrates how transfer learning can overcome data scarcity in rare diseases and provides a robust methodology for automated MRI segmentation in both research and clinical applications.Publicationtype: Journal Article26 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , HARadNet: Anchor-free target detection for radar point clouds using hierarchical attention and multi-task learningTarget localization and classification from radar point clouds is a challenging task due to the inherently sparse nature of the data with highly non-uniform target distribution. This work presents HARadNet, a novel attention based anchor free target detection and classification network architecture in a multi-task learning framework for radar point clouds data. A direction field vector is used as motion modality to achieve attention inside the network. The attention operates at different hierarchy of the feature abstraction layer with each point sampled according to a conditional direction field vector, allowing the network to exploit and learn a joint feature representation and correlation to its neighborhood. This leads to a significant improvement in the performance of the classification. Additionally, a parameter-free target localization is proposed using Bayesian sampling conditioned on a pre-trained direction field vector. The extensive evaluation on a public radar dataset shows an substantial increase in localization and classification performance.Publicationtype: Journal Article47 10