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Item type:Publication, Access status: without files , Combining Direct 3D Volume Rendering and Magnetic Particle Imaging to Advance Radiation-Free Real-Time 3D Guidance of Vascular InterventionsPurpose: Magnetic particle imaging (MPI) is a novel tomographic radiation-free imaging technique that combines high spatial resolution and real-time capabilities, making it a promising tool to guide vascular interventions. Immediate availability of 3D image data is a major advantage over the presently used digital subtraction angiography (DSA), but new methods for real-time image analysis and visualization are also required to take full advantage of the MPI properties. This laboratory study illustrates respective techniques by means of three different patient-specific 3D vascular flow models. Material and Methods: The selected models corresponded to typical anatomical intervention sites. Routine patient cases and image data were selected, relevant vascular territories segmented, 3D models generated and then 3D-printed. Printed models were used to perform case-specific MPI imaging. The resulting MPI images, direct volume rendering (DVR)-based fast 3D visualization options, and their suitability to advance vascular interventions were evaluated and compared to conventional DSA. Results: The experiments illustrated the feasibility and potential to enhance image interpretation during interventions by using MPI real-time volumetric imaging and problem-tailored DVR-based fast (approximately 30 frames/s) 3D visualization options. These options included automated viewpoint selection and cutaway views. The image enhancement potential is especially relevant for complex geometries (e.g., in the presence of superposed vessels). Conclusion: The unique features of the as-yet preclinical imaging modality MPI render it promising for guidance of vascular interventions. Advanced fast DVR could help to fulfill this promise by intuitive visualization of the 3D intervention scene in real time.Publicationtype: Journal Article301 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Toward employing the full potential of magnetic particle imaging: Exploring visualization techniques and clinical use cases for real-time 3D vascular imagingMagnetic particle imaging (MPI) is a relatively young, radiation-free imaging modality that measures the interaction between superparamagnetic nanoparticles and magnetic fields. Compared to standard imaging modalities, a key feature of MPI is its ability to measure 3D volumes of relatively high spatial resolution in real-time, while still maintaining high sensitivity. Therefore, MPI is considered promising especially for vascular imaging and interventions. Yet, to fully take advantage of the unique MPI properties, real-time 4D imaging has to be combined with appropriate real-time 4D visualization and image analysis techniques. The current work aims at identification of respective clinical use cases and scenarios to illustrate the potential of MPI in the context of vascular imaging and interventions; the implementation and exploration of suitable visualization and image analysis techniques; and evaluation and comparison of the resulting image data to standard clinical imaging approaches. The study is based on three clinical use cases and associated anatomical sites: mechanical thrombectomy (anatomical structure: middle cerebral artery, segments M1 and M2); endovascular coiling (internal carotid artery aneurysm); and chemoembolization (proper hepatic artery). Implemented visualization and image analysis options are based on direct volume rendering and cover aspects like optimal view point and view angle selection and application of cut-away views. We illustrate that combining MPI imaging and 4D visualization helps to improve vascular image interpretation.Publicationtype: Conference Paper214