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    CRC 1615 - Project A04: Self-regulating enhanced surfaces for autonomously operated bioprocesses
    This project focuses on the development of microsystem substrates and the integration of smart materials enabling enhanced surfaces for bioprocesses. The enzymatic cofactor regeneration of NAD to NADH by hydrogenase using in situ generated H2 will be taken as a model reaction. This model reaction will be realised in a microsystem carrier with integrated electrodes and optical waveguides enabling space-resolved biocatalytic reaction sequences with controllable individual steps. Our novel approach of combining 3D manufacturing with microsystems technology will pave the ground for a new generation of adaptive components for future SMART bioreactors.
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    CRC 1615 - Project A08: Lagrangian devices with a validated model in multi-particle tracking
    Project A08 will develop Lagrangian devices that can function as sensors and actuators and are substantially smaller than existing Lagrangian sensors. To enable accurate tracking of multiple particles, we will integrate sensor readings from the devices with a newly developed real-time model for their trajectories. This will deliver a high fidelity tracking mechanism that is robust and can cope with issues like noise, missing or ambiguous data and other adverse effects. Ultimately, this will allow the sensors to provide a comprehensive view of the internal state of a chemical reactor and enable their use for closed-loop control.
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