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Item type:Publication, Access status: with files , Bioreactive separation technology: a retrospective and perspective(Elsevier, 2026-03-28); ; ; ; Bluemke, WilfriedBiocatalysis, using enzymes or whole cells, offers high selectivity under mild conditions, but its broader application is often hindered by slow kinetics, equilibrium limitations, product inhibition and the processing of dilute streams in the presence of enzymes and cells. Bioreactive separation, defined as the simultaneous process of biocatalysis and separation, provides a powerful concept to overcome these barriers and therefore offers the potential of superiority over conventional processes. The current retro- and perspective paper, which is the result of an interdisciplinary workshop with academic and industry experts from the areas of biotechnology, fluid separations and process systems engineering, provides a focussed review, paired with a distinct novel definition of bioreactive separations that links to multifunctional reactors in chemical engineering and in situ product removal in biocatalysis. By establishing a common framework, this definition connects different research areas and enables systematic development. The current status of bioreactive separation processes is evaluated using SWOT analyses to identify key potentials and challenges. Based on this, a vision for 2040 is outlined, highlighting the need for advances in integration strategies, biocatalyst design, modelling and simulation, and applied research. Overall, a coordinated progress in these areas can significantly enhance the scalability and sustainability of bioprocessing.Publicationtype: Review Article48 31 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Evaluation of the potential of a deep eutectic solvent for liquid-liquid extraction of furfural using optimization-based process designReducing our environmental impact is the greatest challenge of our time and affects all areas of the chemical, biochemical, and pharmaceutical industries. The use of sustainable and biodegradable solvents in downstream processes, such as deep eutectic solvents (DESs), is one essential step in this direction. While many studies have focused on the investigation of- the thermo-physical properties of DESs, relatively little attention has been paid to solvent regeneration in the context of a closed-loop process, assuming a simple recovery due to the negligible vapor pressure of the DES. In order to evaluate the suitability of this assumption, the current work performs an optimization-based process design for the recovery of furfural from a diluted fermentation broth by liquid-liquid extraction, comparing a previously screened DES with toluene as an established organic solvent. The comparison reveals important limitations of the DES due to considerable water content in the raffinate and the high boiling point resulting in a more complex and energy-demanding process.Publicationtype: Conference Paper41 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Salt influence on MIBK/water liquid-liquid equilibrium: measuring and modeling with ePC-SAFT and COSMO-RS(Science Direct, 2015-11-30); ; ; ; In biotechnological processes, salts might be present during reaction steps and in downstream processes. Salts are known to have a strong impact on phase equilibria of aqueous systems.In this work, the liquid-liquid equilibria (LLE) of ternary salt/MIBK/water mixtures were measured at 298.15 K and 1 bar up to the salt solubility limit. The salts studied in this work were NaCl, LiCl, KCl, NaNO3, LiNO3, Na2SO4, CH3COONa, and CH3COOLi. From these LLE measurements it was found that a high amount of salt is dissolved in the aqueous phase whereas only a very small amount of salt was detected in the MIBK phase. Further, the salting-out behavior of MIBK from the aqueous phase upon addition of different salts was investigated to study ion-specific effects.Two ion-specific models, ePC-SAFT and an extended version of COSMO-RS for electrolytes were used for modeling the binary system MIBK/water and ternary salt/MIBK/water systems. In case of the COSMO-RS based approach, the modeling results were fully predictive. In contrast, ion-specific binary interaction parameters between MIBK and ions were fitted to experimental LLE data of the ternary systems salt/MIBK/water when using ePC-SAFT. The results show that the COSMO-RS based approach allows for predicting the salt influence on LLE with acceptable accuracy, whereas ePC-SAFT allows for almost quantitative correlations of experimental data.Publicationtype: Journal Article193