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Item type:Publication, Access status: without files , Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheresIn this study, the aerogel technology was used to prepare pulmonary drug carriers consisting of alginate and alginate–hyaluronic acid by an emulsion gelation technique and supercritical CO2 drying. During the preparation process, the emulsification rate and inner phase viscosity were varied to control the diameter of aerogel microspheres. Results showed that the aerogel microspheres were highly porous (porosity > 98%) with low densities in the range between 0.0087 and 0.0634 g/cm3 as well as high surface areas between 354 and 759 m2/g. The obtained microspheres showed aerodynamic diameter below 5 µm making them suitable for pulmonary drug delivery. An in vitro drug release study with the model drug sodium naproxen was conducted and a non-Fickian drug release mechanism was observed, with no significant difference between the release profiles of alginate and alginate–hyaluronic acid microspheres. During the emulsion gelation step, the feasibility of using the capillary number to estimate the largest stable droplet size in the emulsions was also studied and it was found that using this number, the droplet size in the emulsions may well be predicted.Publicationtype: Journal ArticleScopus© Citations 18 134 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Alginate and hybrid alginate-hyaluronic acid aerogel microspheres as potential carrier for pulmonary drug delivery(2019-08); ; ; ; The aim of the present study was the preparation of aerogel microspheres based on alginate and hyaluronic acid for the potential application in pulmonary drug delivery. Both polymers are commonly used in the pharmaceutical and medical fields because of their nontoxicity, biodegradability and biocompatibility characteristics. The bio-based microspheres were produced using an emulsion gelation process with a subsequent drying step by supercritical CO 2 . The microspheres were characterized by FTIR and SEM. Furthermore, their BET surface area, particle size distribution, and their aerodynamic properties were determined. The microspheres showed a low density in the range of 0.035 – 0.063 g/cm 3 and a high porosity of 97.6–98.7 %, as well as good in vitro aerodynamic properties with d A values of about 5 μm. The obtained properties of the alginate- hyaluronic acid microspheres suggest that they are potentially suitable as drug carrier for pulmonary delivery.Publicationtype: Journal Article231