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Item type:Publication, Access status: with files , Influence of particle size distribution and contact models on tablet compaction: a DEM micromechanical study(Elsevier, 2026-04-04); ; ; ; The tableting process relies on understanding how particle-scale properties influence macroscopic tablet behaviour. This study examines the effects of particle size distribution (PSD) and contact models on tablet compaction using the Discrete Element Method (DEM). The PSD analysis shows that broader distributions achieve higher final densities and reduced elastic recovery. To assess the impact of contact mechanics, two cohesive DEM models, Hertz–Mindlin with Johnson–Kendall–Roberts (JKR) adhesion and the Edinburgh Elasto-Plastic Adhesion (EEPA) model, were compared under identical compaction kinematics. While both models follow similar loading behaviour, the EEPA formulation retains more of the imposed deformation during unloading, resulting in higher final densities, lower elastic recovery, and a more persistent contact structure than the elastic–adhesive Hertz–Mindlin–JKR model. These results emphasise the importance of both PSD design and contact-model selection when predicting compaction behaviour and final tablet structure in DEM-based analysis of cohesive powders.Publicationtype: Journal Article6 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Influence of process parameters and particle size distribution on mechanical properties of tablets(Wiley-VCH, 2023-01); ; ; ; The influence of the particle size distribution of maltodextrin powders with a dextrose equivalent level of 29 as well as two tableting process variables, namely the compression pressure and the dwell time, on the tensile strength, porosity, and pore size distribution of the final tablet was studied. The mechanical strength and porosity of the tablets are assessed in relation to the powder and process parameters. Regarding the process parameter, it was show that the compaction pressure clearly has a more pronounced influence on the tablet porosity and mechanical strength compared to the influence of the dwell time in the range of the study. As a result, the study offers a better understanding of how the properties of a tablet are influenced by the inter-correlation of powder characteristics and tableting parameters. Therefore, the shelf-life studies and tablet downstream processing as well as drug product development will benefit greatly from this work.Publicationtype: Journal ArticleScopus© Citations 2 64 134