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Item type:Publication, Access status: without files , Ruthenium isotopes show the Chicxulub impactor was a carbonaceous-type asteroid(American Association for the Advancement of Science (Assoc.), 2024-08-16)32 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease(American Association for the Advancement of Science (Assoc.), 2021-04-02); ; ; ; The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease. In a search for a drug against COVID-19, we have performed a high-throughput X-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication. In contrast to commonly applied X-ray fragment screening experiments with molecules of low complexity, our screen tested alreadyapproved drugs and drugs in clinical trials. From the three-dimensional protein structures, we identified 37 compounds that bind to Mpro. In subsequent cell-based viral reduction assays, one peptidomimetic and six nonpeptidic compounds showed antiviral activity at nontoxic concentrations. We identified two allosteric binding sites representing attractive targets for drug development against SARS-CoV-2.Publicationtype: Journal ArticleScopus© Citations 214 186 281 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Scaling behavior of stiffness and strength of hierarchical network nanomaterials(2021-03-05); ; ; ; Structural hierarchy can enhance the mechanical behavior of materials and systems. This is exemplified by the fracture toughness of nacre or enamel in nature and by human-made architected microscale network structures. Nanoscale structuring promises further strengthening, yet macroscopic bodies built this way contain an immense number of struts, calling for scalable preparation schemes. In this work, we demonstrated macroscopic hierarchical network nanomaterials made by the self-organization processes of dealloying. Their hierarchical architecture affords enhanced strength and stiffness at a given solid fraction, and it enables reduced solid fractions by dealloying. Scaling laws for the mechanics and atomistic simulation support the observations. Because they expose the systematic benefits of hierarchical structuring in nanoscale network structures, our materials may serve as prototypes for future lightweight structural materials.Publicationtype: Journal Article125 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Imaging-based molecular barcoding with pixelated dielectric metasurfaces(American Association for the Advancement of Science (Assoc.), 2018-06-08); ; 12 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Comment on "Nonreciprocal light propagation in a silicon photonic circuit"(American Association for the Advancement of Science (Assoc.), 2012-01-06); ; ; ; We show that the structure demonstrated by Feng et al. (Reports, 5 August 2011, p. 729) cannot enable optical isolation because it possesses a symmetric scattering matrix. Moreover, one cannot construct an optical isolator by incorporating this structure into any system as long as the system is linear and time-independent and is described by materials with a scalar dielectric function.Publicationtype: Journal Article145 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , A material with electrically tunable strength and flow stress(American Association for the Advancement of Science (Assoc.), 2011-06-03); The selection of a structural material requires a compromise between strength and ductility. The material properties will then be set by the choice of alloy composition and microstructure during synthesis and processing, although the requirements may change during service life. Materials design strategies that allow for a recoverable tuning of the mechanical properties would thus be desirable, either in response to external control signals or in the form of a spontaneous adaptation, for instance in self-healing. We have designed a material that has a hybrid nanostructure consisting of a strong metal backbone that is interpenetrated by an electrolyte as the second component. By polarizing the internal interface via an applied electric potential, we accomplish fast and repeatable tuning of yield strength, flow stress, and ductility. The concept allows the user to select, for instance, a soft and ductile state for processing and a high-strength state for service as a structural material.Publicationtype: Journal Article10