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Item type:Publication, Access status: without files , Redox-responsive inorganic fluorescent nanoprobes for serodiagnosis and bioimaging(2024-06-15); ; ; Redox reactions play fundamental roles in life and are at the core of metabolism. Thus, observing and quantifying these reactions is crucial for diagnostics and therapy. Recent advances in inorganic fluorescent nanoprobes have revolutionized the field, enabling in vitro diagnostics by providing reliable tools for real-time, quantitative determination of redox biomolecule levels in biological samples and cells. Due to their high stability, these probes are also widely used in bioimaging, providing real-time information for in vivo diagnostics and guiding treatment of diseases associated with redox biomolecules. This review explores the diverse landscape of inorganic fluorescent nanoprobes designed for the detection of biologically relevant reactive oxygen and nitrogen species. The discussion is divided into several sections, each focusing on nanoprobes tailored for specific oxidative species. The impact of tailored nanoprobes in diagnostics and imaging-guided treatment depends on their chemical composition, surface property, and fluorescence mechanism. The discussions highlight the current strengths and weaknesses, which will help to design more efficient redox-responsive inorganic fluorescent nanoprobes in the future.Publicationtype: Review Article8 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Customized Enhancement of Thermal Sensitivity of Tumors at Different Subcutaneous Depths by Multichannel Lanthanide Nanocomposites(2024-06-06); ; 9 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Multi-Channel Lanthanide Nanocomposites for Customized Synergistic Treatment of Orthotopic Multi-Tumor Cases(2023-07-24); ; Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo-induced apoptosis, caused by individual intratumoral differences. Here, a multi-channel lanthanide nanocomposite was used to achieve tailored synergistic treatment of multiple subcutaneous orthotopic tumors under non-uniform whole-body infrared irradiation prescription. The nanocomposite reduces intratumoral glutathione by simultaneously activating the fluorescence and photothermal channels. The fluorescence provides individual information on different tumors, allowing customized prescriptions to be made. This enables optimal induction of hyperthermia and dosage of chemo drugs, to ensure treatment efficacy, while avoiding overtherapy. With an accessional therapeutic laser system, customized synergistic treatment of subcutaneous orthotopic cancer cases with multiple tumors is possible with both high efficacy and minimized side effects.Publicationtype: Journal Article5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Fragmentation and refinement behavior and underlying thermodynamic mechanism of WC reinforcement during selective laser melting of Ni-based compositesThe WC-reinforced Inconel 718 composites were successfully fabricated through selective laser melting (SLM) additive manufacturing technology. Influences of the applied laser energy densities on the thermodynamics within the molten pool, fragmentation behavior of WC particles, and underlying fragmentation mechanism were investigated through experiments and simulations. The results revealed that the fragmentation behavior of WC particles was greatly dependent on the applied laser energy input. As a relatively low laser energy density was applied, the alloyed reaction layer formed around WC particles, and then experienced a fragmentation into a certain number of carbides in the vicinity of WC particles, due to the temperature gradient and resultant thermal tensile stress exerted at the interface of WC particles and molten Inconel 718 alloy. This fragmentation of WC particle was defined as the dissolution-diffusion-fragmentation mechanism. For an elevated laser energy density of 330 J/m was used, an increased temperature gradient and attendant thermal stress formed, and the initially incorporated WC particles experienced a severe heat damage, thereby directly fragmenting the WC particles into the refined pieces. Meanwhile, the molten liquid with more intense thermal convections favored the homogeneous distribution of the broken WC particles and the formation of the alloyed reaction layer between WC particles and molten Inconel 718 alloy liquid, which was predominated by the fragmentation-dissolution-diffusion mechanism.Publicationtype: Journal Article31