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Item type:Publication, Access status: with files , Novel synthetic clot analogs for in-vitro stroke modelling(Public Library of Science (PLoS), 2022-09-09); ; ; ; Purpose The increased demand for training of mechanical thrombectomy in ischemic stroke and development of new recanalization devices urges the creation of new simulation models both for training and device assessment. Clots properties have shown to play a role in procedural planning and thrombectomy device effectiveness. In this study, we analyzed the characteristics and applicability of completely synthetic, animal-free clots in the setting of an invitro model of mechanical thrombectomy for training and device assessment. Methods Synthetic clots based on agarose (n = 12) and silicone (n = 11) were evaluated in an in-vitro neurointervention simulation of mechanical thrombectomy with clot extraction devices. Calcified clots of mixed nature were simulated with addition of 3D printed structures. 9 clots were excluded due to insufficient vessel occlusion and failure to integrate with clot extraction device. Synthetic thrombi were characterized and compared using a categorical score-system on vessel occlusion, elasticity, fragmentation, adherence and device integration. Results Both agarose-based and silicone-based clots demonstrated relevant flow arrest and a good integration with the clot extraction device. Silicone-based clots scored higher on adherence to the vessel wall and elasticity. Conclusion Selected synthetic clots can successfully be implemented in an in-vitro training environment of mechanical thrombectomy. The clots' different properties might serve to mimic fibrin-rich and red blood cell-rich human thrombi.Publicationtype: Journal ArticleScopus© Citations 1 55 85 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Development of synthetic thrombus models to simulate stroke treatment in a physical neurointerventional training model(Taylor & Francis, 2022-03-04); ; ; ; In an ischaemic stroke, a blood clot (thrombus) occludes one of the arteries supplying the brain with oxygen. In such cases, a prompt and safe removal of the thrombus by interventional physicians is of high importance. The procedure of mechanical thrombectomy is mainly trained on animal models or simple flow models with animal- or human-based thrombi. The aim of this study is to develop a completely blood free thrombus model for use in an existing physical neurointerventional simulation model. Based on requirements established with treating physicians and supplemented by a broad literature review, a systematic material selection based on mechanical properties was performed by means of a material database. Selected materials, as well as other materials from a literature search and structural additive manufactured clots, were produced and selectively narrowed down, by means of functional property testing. Based on a pre-selection by a simple test set-up, the main tests were carried out on the existing simulation model by interventional physicians under realistic test conditions in a clinical angiography suite. As a result, four different types of thrombi varying in elasticity, solidity and fragmentation, were obtained by material combinations based on agarose and silicone in different concentrations and with further additives.Publicationtype: Journal ArticleScopus© Citations 2 70 597