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Item type:Publication, Access status: with files , Hidden diversity : diversity of cells in industrial bioprocessesPopulation heterogeneity poses a major challenge in industrial scale bioprocesses, affecting process performance but also leading to more robust phenotypes. To investigate this phenomenon, multiple fluorescent reporter strains are cultivated under simulated industrial scale conditions in multi-compartment bioreactors. This approach significantly raises the quantitative understanding of population heterogenity which is needed before its benefits can help to develop high-yielding, more robust bioprocesses.Publicationtype: Journal Article63 59 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Produktion von Plattformchemikalien durch mikrobielle BiokatalysatorenThe application of organic carbon as a biotechnological substrate belongs to the most promising approaches for the substitution of unsustainable production systems. Here, we present Cupriavidus necator as production strain for catalyzing the conversion of carbon dioxide, butyrate, acetate and propionate to the platform chemical acetoin. Using genetic engineering and proteomics the optimization of the strain is put into perspective regarding its implementation in a biorefi nery context.Publicationtype: Journal Article84 59 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , 32 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Bioplastikproduktion mithilfe eines extremophilen kathodischen Biofilms(2020-11-25); ; ; As the atmospheric CO2 concentrations are increasing, its usage as biotechnological substrate becomes a focus area of applied scientists. As a rather new technique to energize the process of CO2 fixation, microbial electrosynthesis offers the advantage to establish continuous processes based on a cathodic biofilm that is supplied with electrical energy provided by renewable resources. Here we present the cathodic biofilm growth of Kyrpidia spormannii, a recently isolated thermophilic organism that is naturally capable of producing the biodegradable biopolymer polyhydroxybutyrate (PHB).Publicationtype: Journal Article59 129 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Kultivierung und Analyse von Biofilmen durch automatisierte MikrosystemeBiofilms are the most abundant growth form of microorganisms in nature. To exploit these living systems for applications in biotechnology, we have developed a microfluidic cultivation platform with an integrated automatic sampling robot that enables the characterization of biofilms with high spatiotemporal resolution. Moreover, in situ imaging and anoxic or gas-consumption based cultivation can be applied. Biocatalytic productivity can be assessed using a spectrum of analytical technologies.Publicationtype: Journal Article68 126 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Elektrofermentation von Acetoin(2018-02-01); ; Electrode-assisted fermentation is a new strategy in anaerobic biotechnology. It can be used for reactions in which the average oxidation state of the end product is higher than the substrate. Here we show two applications of an electrode-assisted fermentation for the anoxic production of acetoin. The presented approaches in Shewanella oneidensis and Escherichia coli utilize engineered metabolisms to achieve high product yields of roughly 80 percent under strictly anoxic conditions.Publicationtype: Journal Article28 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Biochemical synthesis: Combinatorial chemistry in high-density array format(2016-09-01); ; Nesterov-Müller, AlexanderWe synthesize peptide arrays by using laser pulses to transfer amino acids onto a synthesis slide that are embedded in a polymer. After patterning these razor-thin spots, the coupling starts by heating the polymer that now serves as a solvent to couple monomers to the surface. The main advantages of this nanolayer solid phase chemistry are the high degree of automation, the very high spot density, and the in situ activation of monomers due to mixing different reagents in the stacked nanolayers.Publicationtype: Journal Article4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Cell culture techniques: Current trends in the in vitro substance testing in Germany and Switzerland(Sektrum, 2014-06-19); ; ; ; Publicationtype: Journal Article35 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , DECHEMA/VAAM-Fachgruppe „Biotransformationen“ : Biotechnologie von Morgen [Biotechnology of tomorrow: DECHEMA/VAAM Specialized Group "Biotransformations"](Spektrum, 2013-04-13); ; ; ; Publicationtype: Journal Article51 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Proteindesign für die Entwicklung von industriellen Mikroorganismen : Metabollic Engineering [Metabolic engineering : protein design for the development of industrial microorganisms]The fast and efficient development of industrial microorganisms for the production of new compounds requires an integrated interplay of various approaches to manipulate cell metabolism from atomic to systems level. Techniques from systems and synthetic biology, like protein modeling and design, greatly enhance our capabilities of metabolic engineering. Here, we illustrate some current strategies and recent achievements of protein design in the context of metabolic engineering.Publicationtype: Journal Article38