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Item type:Publication, Access status: with files , Enhancing interfacial charge transport in Gold Nanoparticle@Polyaniline hybrids via N-heterocyclic carbene linkersN-Heterocyclic carbenes (NHCs) have emerged as a unique class of ligands for gold nanoparticles (Au NPs), combining strong metal binding with intrinsic electronic conductivity. Yet over the past decade, studies on Au NP@NHC systems have primarily focused on their stability, while the conductivity of NHCs has remained largely unexplored due to synthesis challenges. Here, we present a synthetic strategy that addresses this gap by employing amino-functionalized NHC-Au complexes with in situ oxidative polymerization of polyaniline (PANI) to yield electronically coupled Au NP@NHC-PANI hybrids in aqueous media. This strategy enables both a controlled PANI shell growth and introduction of an electronically active NHC interlayer. Single-particle scattering spectroscopy reveals that NHCs improve the interfacial electronic coupling as evidenced by pronounced plasmonic linewidth broadening. Conductivity measurements further confirm that NHCs enhance charge transport: conductive atomic force microscopy (C-AFM) shows an increase in contact current from 14.6 to 99.4 pA under a 300-mV bias, while lateral four-probe conductance increases from 0.17 to 3.5 nS. These results provide the first direct experimental evidence of the conductive role of NHCs in hybrid NP-polymer systems, establishing a new interface-engineering strategy for the rational design of electronically delocalized nanostructures and their applications in nanoelectronics.Publicationtype: Journal Article58 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Synthetic High-Throughput Microarrays of Peptidoglycan Fragments as a Novel Sero-Diagnostic Tool for Patient Antibody Profiling(2025-04-25); ; ; ; Peptidoglycan (PGN) is a complex biopolymer crucial for cell wall integrity and function of all bacterial species. While the strong inflammatory properties of PGN and its derived muropeptides are well-documented in human innate immune responses, adaptive immunity, including antibody responses to PGN, remain inadequately characterized. Microarray technology represents a cost- and time-efficient method for studying such interactions. Our laser-based technology enables the high-throughput synthesis of biomolecules on functionalized glass slides. Here, this on-chip synthesis was developed for PGN fragments, to generate a variety of 216 stem peptides and attach six different glycan moieties that are major structural components of bacterial cell walls. Thereby, 864 PGN fragments from different Gram-negative and Gram-positive species were generated. The arrays were validated with four different monoclonal antibodies against PGN or poly-N-acetyl glucosamine and identified their epitopes. Finally, proof of concept for antibody profiling in patient samples was performed by comparing a panel of well-characterized plasma samples of epidermolysis bullosa (EB) patients suffering from (chronic) wounds with Staphylococcus aureus infection. EB patients show an increased response to the muramyl dipeptide. Therefore, this novel high-throughput PGN glycopeptide microarray technology promises to identify distinct antibody profiles against human microbiomes in diseases, notably in those involving the intestine.Publicationtype: Journal Article21 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , N-Heterocyclic carbene vs. thiophene – chiral adsorption and unidirectional rotation on Au(111)(Wiley-VCH, 2025-03-12); ; 32 16 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Multiplying oxygen permeability of a Ruddlesden‐Popper oxide by orientation control via magnets(Wiley, 2024-02-19); ; ; ; Ruddlesden-Popper-type oxides exhibit remarkable chemical stability in comparison to perovskite oxides. However, they display lower oxygen permeability. We present an approach to overcome this trade-off by leveraging the anisotropic properties of Nd₂NiO₄+δ. Its (a,b)-plane, having oxygen diffusion coefficient and surface exchange coefficient several orders of magnitude higher than its c-axis, can be aligned perpendicular to the gradient of oxygen partial pressure by a magnetic field (0.81 T). A stable and high oxygen flux of 1.40 mL min−1 cm−2 was achieved for at least 120 h at 1223 K by a textured asymmetric disk membrane with 1.0 mm thickness under the pure CO₂ sweeping. Its excellent operational stability was also verified even at 1023 K in pure CO₂. These findings highlight the significant enhancement in oxygen permeation membrane performance achievable by adjusting the grain orientation. Consequently, Nd₂NiO₄+δ emerges as a promising candidate for industrial applications in air separation, syngas production, and CO2 capture under harsh conditions.Publicationtype: Journal Article28 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Inside cover : multiplying oxygen permeability of a Ruddlesden‐Popper oxide by orientation control via magnets (Angew. Chem. 8/2024)(Wiley, 2024-01-18); ; ; ; Publicationtype: Journal Article22 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Multi-Channel Lanthanide Nanocomposites for Customized Synergistic Treatment of Orthotopic Multi-Tumor Cases(2023-07-24); ; Simultaneous photothermal ablation of multiple tumors is limited by unpredictable photo-induced apoptosis, caused by individual intratumoral differences. Here, a multi-channel lanthanide nanocomposite was used to achieve tailored synergistic treatment of multiple subcutaneous orthotopic tumors under non-uniform whole-body infrared irradiation prescription. The nanocomposite reduces intratumoral glutathione by simultaneously activating the fluorescence and photothermal channels. The fluorescence provides individual information on different tumors, allowing customized prescriptions to be made. This enables optimal induction of hyperthermia and dosage of chemo drugs, to ensure treatment efficacy, while avoiding overtherapy. With an accessional therapeutic laser system, customized synergistic treatment of subcutaneous orthotopic cancer cases with multiple tumors is possible with both high efficacy and minimized side effects.Publicationtype: Journal Article5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Poly(3-hexylthiophene)s Functionalized with N-Heterocyclic Carbenes as Robust and Conductive Ligands for the Stabilization of Gold Nanoparticles(2021-02-19); ; ; ; Recently, N-heterocyclic carbenes (NHCs) are explored as anchor groups to bind organic ligands to colloidal gold (i.e. gold nanoparticles, Au NPs), yet these efforts are confined to non-conjugated ligands so far—that is, focused solely on exploiting the stability aspect. Using NHCs to link Au NPs and electronically active organic components, for example, conjugated polymers (CPs), will allow capitalizing on both the stability as well as the inherent conductivity of the NHC anchors. Here, we report three types of Br-NHC-Au-X (X=Cl, Br) complexes, which, when used as starting points for Kumada polymerizations, yield regioregular poly(3-hexylthiophenes)-NHC-Au (P3HTs-NHC-Au) with narrow molecular weight distributions. The corresponding NPs are obtained via direct reduction and show excellent thermal as well as redox stability. The NHC anchors enable electron delocalization over the gold/CP interface, resulting in an improved electrochromic response behavior in comparison with P3HT-NHC-Au.Publicationtype: Journal ArticleScopus© Citations 19 18 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Prospects of Coupled Organic–Inorganic Nanostructures for Charge and Energy Transfer Applications(2021-01-18); ; ; ; We review the field of organic–inorganic nanocomposites with a focus on materials that exhibit a significant degree of electronic coupling across the hybrid interface. These nanocomposites undergo a variety of charge and energy transfer processes, enabling optoelectronic applications in devices which exploit singlet fission, triplet energy harvesting, photon upconversion or hot charge carrier transfer. We discuss the physical chemistry of the most common organic and inorganic components. Based on those we derive synthesis and assembly strategies and design criteria on material and device level with a focus on photovoltaics, spin memories or optical upconverters. We conclude that future research in the field should be directed towards an improved understanding of the binding motif and molecular orientation at the hybrid interface.Publicationtype: Journal ArticleScopus© Citations 42 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: with files , Iron(II)-catalyzed biomimetic aerobic oxidation of alcoholsWe report the first FeII-catalyzed biomimetic aerobic oxidation of alcohols. The principle of this oxidation, which involves several electron-transfer steps, is reminiscent of biological oxidation in the respiratory chain. The electron transfer from the alcohol to molecular oxygen occurs with the aid of three coupled catalytic redox systems, leading to a low-energy pathway. An iron transfer-hydrogenation complex was utilized as a substrate-selective dehydrogenation catalyst, along with an electron-rich quinone and an oxygen-activating Co(salen)-type complex as electron-transfer mediators. Various primary and secondary alcohols were oxidized in air to the corresponding aldehydes or ketones with this method in good to excellent yields.Publicationtype: Journal ArticleScopus© Citations 32 171 424 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Access status: without files , Metasurface-based molecular biosensing aided by artificial intelligence(Wiley, 2019-04-25); 8